Thu8

06:15 AM

day:
Thursday
date:
11/08/2018
time:
6:15 AM - 7:15 AM
event:
ITE Review- Morphine:Metabolites
location:
OR Classroom B
type:
Class
department:
Anesthesiology
audience:
details:
ITE Review- Morphine:Metabolites
isCME:
No
speakers:
Dr. Emily Smith-Straesser
registration:
No registration is necessary
contact:
Leslie Walker LAW9XC@hscmail.mcc.virginia.edu
day:
Thursday
date:
11/08/2018
time:
9:30 AM - 10:30 AM
event:
"Deciphering Mechanisms of Substrate Targeting by Protein Kinases" by Benjamin Turk
location:
PINN 1-17
type:
Seminar
department:
Pharmacology
audience:
Faculty Students
details:
Hosted by John Fu, Ben Turk, PhD, is an Associate Professor of Pharmacology, School of Medicine, Yale University, New Haven, CT


Research interests:


Deciphering mechanisms of substrate targeting by protein kinases

The completion of the human genome a decade ago revealed more than 500 genes encoding protein kinases, and mass spectrometry based phosphoproteomics efforts have now cataloged over 100,000 sites of phosphorylation in mammalian cells. These studies have clearly outpaced our ability to understand signaling networks through analysis of individual kinases and their substrates: for the vast majority of the phosphorylation sites, the responsible kinase and functional significance are simply not known. My group studies basic mechanisms used by kinases to target specific substrates within the cell, with the idea of applying this knowledge to identify new kinase-substrate pairs on a proteomic scale. Kinases interact with their substrates through short sequence motifs found both at the site of phosphorylation and at distal sites. We develop methodology that allows for the rapid identification of these protein kinase recognition motifs. Using synthetic peptide arrays, we have recently conducted a biochemical screen to identify phosphorylation site motifs recognized by the entire set of kinases from budding yeast, and a similar screen of the human kinome is in progress. Information from these screens is used to map cellular phosphorylation networks and to relate mechanisms of substrate targeting to specific structural features of kinases.
URL:
https://medicine.yale.edu/lab/turk/labmembers/
isCME:
No
speakers:
Ben Turk, PhD, Associate Professor of Pharmacology, School of Medicine, Yale University, New Haven, CT
registration:
No registration is necessary
contact:
Antoinette Reid Pharmacology 434-924-1919 adw2n@Virginia.EDU
Attachments:
SeminarNotice-Benjamin Turk.pdf
day:
Thursday
date:
11/08/2018
time:
12:00 PM - 1:00 PM
event:
BMG Seminar Dr. Smita Patel, Biochemistry and Molecular Genetics, Rutgers University, "Self and non=self RNA recognition by the innate immune receptor RIG-I"
location:
Pinn Hall 1017
type:
Seminar
department:
Biochemistry, Molecular Biology and Genetics
audience:
Everyone
details:
isCME:
No
registration:
No registration is necessary
contact:
Nancy Rush Biochemistry 3-0087 nr9b@Virginia.EDU
day:
Thursday
date:
11/08/2018
time:
5:45 PM - 6:45 PM
event:
Go Girls! Fitness Support Group
location:
UVA Battle Building OR Orange Pediatrics
type:
Class
department:
Go Girls
audience:
Everyone
details:
Go Girls! is a fun dance-based fitness and education program for girls ages 7-21. Our group meets every week to exercise in a fun environment, make new friends, and support each other in wellness goals. We participate in 45 minutes of dance fun followed by a brief wellness discussion. Go Girls! is free for girls ages 7-21 & female family and friends!

Join us at The Battle Building at the University of Virginia Children's Hospital, 1204 West Main St, Charlottesville, VA.

OR, join us at Orange Pediatrics from 5:30 - 6:30 p.m. - Orange Medical Center, 661 University Lane, Suite A, Orange, VA

Free parking is provided for Go Girls! participants in the 11th street garage. After 5pm use push button/video phone for building access on the W. Main St. entrance or the 3rd floor parking garage entrance (level C). Please bring your parking garage ticket in and get it validated.

Classes are also held on Mondays from 5:45 - 6:45 p.m. at UVA Primary Care Zion Crossroads - UVA Medical Park Zion Crossroads, 1015 Spring Creek Parkway, Zion Crossroads, VA 22942











URL:
https://www.gogirls.virginia.edu/
isCME:
No
registration:
No registration is necessary
http://www.gogirls.virginia.edu/programs/registration
contact:
Anna King Akk8n@hscmail.mcc.virginia.edu

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