Thu21

09:30 AM

day:
Thursday
date:
11/21/2019
time:
9:30 AM - 10:30 AM
event:
"The Role of Mitochondrial ROS Production in Health and Disease"-2019 Joseph Larner Memorial Lecture in Pharmacology by Michael Murphy, PhD
location:
PHCC Auditorioum 1st floor Pinn Hall
type:
Lecture
department:
Pharmacology
audience:
Everyone Students
details:
A lectureship was established to honor the memory of Joseph Larner, who served as Professor and Chair of the Pharmacology Department for many years. During his time as Chair he recruited and mentored numerous successful faculty, including Al Gilman. He continued to be an inspiration to everyone who knew him, especially our graduate students, who were in awe of his energy and enthusiasm as he kept up his science and maintained an active departmental presence well into his 90s. In addition to honoring Dr. Larner’s memory, the goal of this lectureship is to highlight exciting new advances in an area that held great interest for him: the pervasive role of metabolism/cell signaling in human disease.

About this year's speaker:

Hosted by Thurl Harris and Michelle Bland, Michael Murphy is a Professor of Mitochondrial Redox Biology and Programme Leader at the MRC Mitochondrial Biology Unit at the University of Cambridge, UK

Dr. Murphy's Research Interests-

Mitochondrial dysfunction

Reactive oxygen species (ROS) produced by mitochondria cause oxidative damage that impairs the ability of mitochondria to make ATP and to carry out their metabolic functions. They may participate also in cellular redox signalling pathways.

One important aspect of our work is to investigate how oxidative damage to mitochondria contributes to human pathologies. We have worked out a way of targeting small bioactive molecules, such as antioxidants, to mitochondria in order to counter the effects of ROS and to examine the effects of doing so at cellular and whole animal levels. The bioactive molecule is attached chemically to a lipophilic cation such triphenylphosphonium. These cations accumulate selectively, first in the cytosol, driven by the plasma membrane potential, and then several-hundred fold in the matrix of mitochondria, driven by the membrane potential across the inner membrane.

A second important aspect is to determine whether and how mitochondrial ROS alters the activities of proteins in putative signalling and protective pathways by reversibly modifying the redox state of critical protein thiols in mitochondria. We use a range of free radical and proteomic approaches to identify the proteins involved, and to identify the cysteine residues and any redox modifications.

Finally, we take this information and use it to rationally design potential therapies for diseases that arise from mitochondria dysfunction. Currently our main focus for therapy is the ischaemia/reperfusion injury that arises from stroke and heart attack.

URL:
http://www.mrc-mbu.cam.ac.uk/people/mike-murphy
isCME:
No
speakers:
Michael Murphy, PhD, Professor of Mitochondrial Redox Biology and Program Director, MRC Mitochondrial Biology Unit, University of Cambridge, UK
registration:
No registration is necessary
contact:
Antoinette Reid Pharmacology 434-924-1919 adw2n@virginia.edu
Attachments:
Michael Murphy_LectureFlyerTabloid.pdf
day:
Thursday
date:
11/21/2019
time:
6:30 PM - 8:30 PM
event:
Newborn Care Class
location:
University Hospital
type:
Class
department:
OB / Gyn
audience:
Everyone
details:
Prepare for the arrival of your little one! We will cover newborn behavior, sleep patterns and how to calm a fussy baby. Care in the hospital, and basics in baby care will be discussed , along with on going resources.
URL:
https://uvahealth.com/services/pregnancy-birth/prenatal-class-info
isCME:
No
registration:
No registration is necessary
des4v@virginia.edu 434 924 9920
contact:
Diane Sampson 434 924 9920 DES4V@hscmail.mcc.virginia.edu

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