Hosted by Michael Scott, David Olson, MD, PhD is an Assistant Professor, Department of Pediatrics and Communicable Diseases, Medicine, University of Michigan

Using novel mouse models, Dr. Olson is exploring gene expression changes in specific neuronal populations in the brain that are known to be important in regulating energy balance; these studies are directed at examining the link between gene expression in specific areas of the brain and altered metabolism. Additional studies using neuron-specific genetic changes are underway to clarify the molecular basis of daily biologic rhythms and explore how disruption of these rhythms predisposes organisms (rodents and humans) to pathologic changes in metabolism.