Description: Hosted by Irina Bochkis, Joseph Bass, MD, PhD is a Charles F. Kettering Professor of Medicine, Department of Medicine, Feinburg School of Medicine, Chief of the Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Chicago, IL
The primary research focus in our laboratory is to understand the molecular mechanisms through which the circadian clock regulates cell and organismal metabolism and the reciprocal feedback of metabolism on circadian oscillators in animals. Our long-range goal is to exploit insight into the clock to identify regulatory nodes within metabolic pathways important in beta cell biology, mitochondrial function, NAD+ biosynthesis, NAD+ dependent ADP-ribosylation and deacetylation reactions, and to determine the impact of these epigenetic modifications on proliferation and stress response. These studies will elucidate the relationship amongst brain, behavior, and physiology at both the cell and molecular level. We anticipate that a better understanding of clock processes will lead to innovative therapeutics for a spectrum of diseases including diabetes, obesity, autoimmunity, and cancer.