Description: Hosted by Kevin Lynch, Susan R. Schwab is an Associate Professor in the Department of Pathology, Skirball Institute, NYU Langone Health, New York, NY
Schwab Lab studies lymphocyte migration, with an emphasis on three questions:
What determines how long a lymphocyte stays in a given location—surveying for antigens or fighting infection—before it moves on?
How are the gradients that direct immune cell migration established?
How do the trafficking requirements of normal and leukemic T cells differ, and can these differences be targeted therapeutically?
Much of our focus has been on how the residence time of T cells in lymphoid organs is determined. We have established that a gradient of the signaling lipid sphingosine 1-phosphate (S1P) is required to guide T cells out of lymphoid organs. We have also identified many of the key cells and enzymes that control this gradient, and we have developed novel tools to map it. Future work will assess how S1P gradients are regulated during an immune response.