Hosted by Ku-Lung(Ken) Hsu, Edward Dennis, PhD, is a Distinguished Professor of Pharmacology and Chemistry & Biochemistry, School of Medicine, University of California, San Diego, CA

The Dennis laboratory is leading the national NIGMS LIPID MAPS Glue Grant Consortium which is developing LC/MS based lipidomics analysis to map the lipidome by detecting and quantizing the numerous molecular species of lipids in the murine macrophage. We are determining the lipid changes upon cell stimulation by various agonists such as TLR receptor agonists. Our laboratory is focused on identifying the known and discovering new fatty acids and eicosanoid metabolites (prostaglandins and leukotrienes) in these cells and using LC/MS to follow their production upon cell stimulation and determining lipid metabolite fluxes at the cellular level.