Calculation of Creatinine Clearance

Creatinine Clearance (mL/min) =

Urine Creatinine (mg/dL) TotalVolume(mL)

Serum Creatinine(mg/dL) X Time (min)

Creatinine clearance is classically corrected to a body surface area of 1.73 m2 which is the standard body surface area of an adult.  The formula of Dubois and Dubois can be used to calculate the body surface area of a given individual:

A = W0.425 X H0.725 X 0.007184

where:          A = body surface area in m2

W = weight in kg

H = height in cm

 

The calculated clearance for an individual can then be corrected to the standard body surface area using the following formula:

Creatinine Clearance(mL/min/1.73 m2)=Creatinine Clearance X 1.73/A

Reference intervals for corrected creatinine clearances differ between sexes:

Males:          71 - 135 mL/min/1.73 m2

Females:      78 - 116 mL/min/1.73 m2