Adolescent Hormone Study


Assessment of the Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition in Normal and Hyperandrogenemic Adolescent Girls (JCM010)


Marshall John, C

UVa Health System, Center for Research in Reproduction seeks adolescents girls ages 8 – 18 who are experiencing symptoms of elevated male hormone levels (overweight, increased facial or body hair, irregular periods, acne) for a research study. The purpose of the study is to determine how elevated male hormone levels may contribute to the development of polycystic ovary syndrome (PCOS). In this study, we will observe the effects of 7 days of estrogen and progesterone on Gonadotropin-releasing hormone (GnRH) pulses in girls with elevated male hormone levels. The study involves taking estrogen and progesterone which are natural hormones; the study also involves blood draws during outpatient and inpatient visits. There are 5 study visits in total, including two 14-hour overnight admissions to the Clinical Research Unit. The other visits include one screening visit which takes about an hour and two outpatient blood draws which take about 15 minutes. * Study-related exams, tests, and medications are provided free of charge. * Compensation for study completion is $200 in Simon gift cards. Contact Information: For more information please contact: • Anne C Gabel, Clinical Research Coordinator •, 434-243-6911 • IRB-HSR # 8588 Principal Investigator: John C Marshall, MD, PhD


Polycystic Ovarian Syndrome



Compensation for study completion is $200 in Simon gift

Anne Gabel