Reproductive Hormone study in Adult Women.


Influence of hyperandrogenemia on the sleep-associated slowing of follicular LH frequency in adult polycystic ovary syndrome (CRM004)


McCartney Christopher,

The goal of this study is to determine whether testosterone (a male hormone) helps control the secretion of gonadotropin-releasing hormone (GnRH) while awake and while asleep. (GnRH controls the secretion of hormones by the pituitary gland, and pituitary hormones control the production of female hormones from the ovaries.) We are recruiting women with and without PCOS (between 18 and 35 years old). This study involves three outpatient visits, and two 17-hour admissions to GCRC. Volunteers will take flutamide for about 28 days. Flutamide is not approved by the FDA for use in women; however, it is FDA-approved for treatment of prostate cancer. Sleep will be formally monitored during GCRC admissions.


Hormone Studies
Polycystic Ovarian Syndrome
Metabolic Syndrome

Women's Health
Healthy Subjects - Inpatient



Cinthya Yesenia Obando Perez