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George  A.  Beller
Degree(s): M.D.
Graduate School: University of Virginia
Primary Appointment: Professor of Medicine, Cardiovascular Medicine
Research Interests:
Radionuclide Imaging Agents for Cardiac Imaging

Email Address: gab4c@virginia.edu
Research Description

Dr. Beller's lab is engaged in the development of new radionuclide imaging agents for cardiac imaging and validating their worth in animal models of myocardial ischemia, infarction hibernation, and atherosclerosis. New applications of currently utilized imaging agents are also explored in this research laboratory. Most often, nuclear cardiology data are correlated with hemodynamic, biomarker and histological information. More recently, the lab is engaged in examining the value of novel adenosine A2A agonists for reducing myocardial ischemia-reperfusion injury after experimental myocardial infarction. For these experiments, cardiac MR is also utilized to evaluate myocardial infarct size and left ventricular remodeling. Dr. Beller’s clinical research deals with the diagnostic and prognostic value of cardiac imaging techniques, with an emphasis on nuclear cardiology.

Selected Publications
  • Glover DK, Ruiz M, Takehana K, Petruzella FD, Rieger JM, Macdonald TL, Watson DD, Linden J, Beller GA. Cardioprotection by Adenosine A2A Agonists in a Canine Model of Myocardial Stunning Produced by Multiple Episodes of Transient Ischemia. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3164-71.
  • Yang Z, Linden J, Berr SS, Kron IL, Beller GA, French BA Timing of adenosine 2A receptor stimulation relative to reperfusion has differential effects on infarct size and cardiac function as assessed in mice by MRI. Am J Physiol Heart Circ Physiol. 2008 Dec;295(6):H2328-35. Epub 2008 Oct 10.
  • Glover DK, Riou LM, Ruiz M, Sullivan GW, Linden J, Rieger JM, Macdonald TL, Watson DD, Beller GA: Reduction of infarct size and postischemic inflammation from ATL-146e, a highly selective adenosine A2A receptor agonist, in reperfused canine myocardium. Am J Physiol Heart Circ Physiol 288(4):H1851-H1858, 2005. Epub Dec. 9, 2004.
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    Contact Information
      Office Address: PO Box 800158, Hospital Expansion Bldg., 4030, 1215 Lee S, 
      Office Phone: +1 434-924-2134, +1 434-982-0853
      Fax Phone: +1 434-982-1998

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    http://www.healthsystem.virginia.edu/people/dop/dopDetail.cfm?drid=27

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