Rajan A.G. Patel
Degree(s):  B.A., M.D.
Graduate School : Stanford University School of Medicine
 
Research/Clinical Interests:
Cardiovascular disease; Cardiac MRI; Myocardial Reperfusion Injury; Mechanics of Ventricular Remodeling; Interventional MRI

Email Address: rap8b@virginia.edu
Research Description

1) Reperfusion injury after ischemia is an important pathophysiologic mechanism in many cardiovascular diseases including myocardial infarction.  When treating an acute MI, the importance of rapidly reperfusing ischemic myocardium in order to decrease morbidity and mortality is well established.  However, myocardium in the ischemic territory may suffer additional damage upon restoration of blood flow.  CMR provides extremely accurate and reproducible imaging techniques for the serial assessment of left ventricular function, injury, and remodeling.   We are using CMR imaging to assess the efficacy and safety of pharmocologic interventions that may limit reperfusion injury.                   

2) Myocardial injury may result in ventricular remolding and intraventricular dysynchrony.  We are investigating the use of a two-dimensional cine MR pulse sequence based on displacement encoding with stimulated echoes (DENSE) for quantitative myocardial motion tracking.  Data gained from CMR DENSE sequences will provide new insight into the mechanics of adverse ventricular remodeling and dysynchrony.
 
 Selected Publications

  • Patel RAG, Kramer CM, DiMarco JP, Voros S, Akar J. Chagas Myocarditis and Syncope. Journal of Cardiovascular Magnetic Resonance. (in press, August 17, 2005 ).

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