The Gene Targeting and Transgenic Facility (GTTF), formerly the Transgenic Mouse Core Facility (TMCF), of the University of Virginia (UVa) provides user-oriented service to efficiently produce and preserve genetically engineered mouse strains for animal model research for investigators at UVa and their collaborators in other academic institutions.

GTTF’s mission is to support transgenic and gene targeting research endeavors, to advance genetic technologies for germline and ES cell manipulations, and to serve as a resource for design, development and derivation of customized mouse strains.

We welcome you to visit our website and explore information about our services.  Please feel free to contact us.  The UVa Transgenic Methods and Applications Workshop is held several times a year.  You can register for the workshop on line.

An ES cell colony derived from one explanted blastocyst

AP activity detected in undifferentiated NZM 2328 ES cell colonies

Black/white chimera made with one of GTTF-derived B6 ES cell lines

Blastocysts from a GFP knockin mouse