University of Virginia Health System

Kedes DH, Steitz JA. Accurate 5' splice-site selection in mouse kappa immunoglobulin light chain premessenger RNAs is not cell-type-specific. Proc Natl Acad Sci U S A. 1987 Nov; 84(22):7928-32.

Kedes DH, Steitz JA. Correct in vivo splicing of the mouse immunoglobulin kappa light-chain pre-mRNA is dependent on 5' splice-site position even in the absence of transcription. Genes Dev. 1988 Nov; 2(11):1448-59.

Renne, R, Zhong, W, Herndier, B, McGrath, M, Kedes, D and Ganem, D Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in B cell lymphoma cells in culture Nature Medicine Mar. 1996, 2 (3) 342-46.

Kedes, DH, Operskalski E, Busch, M, Kohn, R, Flood, J, and Ganem, D The seroepidemiology of human herpesvirus 8 (KS- associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission Nature Medicine August 1996, 2 (8) p918-24.

Kedes, DH, Ganem, D, Ameli, N, Bacchetti, P and Greenblatt, R The prevalence of serum antibody to human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) among HIV-seropositive and high risk seronegative women JAMA February 1997, 277 (6): 478-81

Goedert, J, Kedes, DH and Ganem, D Antibodies to human herpesvirus 8 in women and infants born in Haiti and the USA Lancet 1997, 349(9062): 1368.

Operskalski EA, Busch MP, Mosley JW, Kedes DH Blood donations and viruses. Lancet (letter) 1997, 349(9061):1327

Kedes, DH and Ganem, D Sensitivity of Kaposi's Sarcoma-associated Herpesvirus Replication to Antiviral Drugs: Implications for Potential Therapy J. Clin. Invest. 1997, 99: 2082-2086.

Diamond, C, Huang, ML, Kedes DH, Speck C, Rankin, GW Jr., Ganem, D, Coombs, RW, Rose, TM, Krieger, JN and Corey, L Absence of Detectable Human Herpes Virus Eight in the Semen of HIV-Infected Men without Kaposi's Sarcoma Journal of Infectious Diseases 1997, 176:775-7.

Kedes, DH, Renne, R, Lagunoff, M and Ganem, D Identification of the Gene Encoding the Major Latency-Associated Nuclear Antigen of the Kaposi's Sarcoma-Associated Herpesvirus J. Clin. Invest. 1997, 100: 2606-2610.

Dittmer, D and Kedes DH Do Viral Chemokines Modulate Kaposi's Sarcoma? Bioessays 1998, 20(5):367-370

Martin, J, Osmond, D, Page-Shafer, KA, Macrae, D, Ganem, D and Kedes, DH Sexual Transmission and Natural History of HHV-8Infection in Homosexual Men: A Population-based Cohort Study NEJM 1998, 338(14):948-954.

O'Brien, T.R., Kedes, DH, Ganem, D, Macrae, DR, Rosenberg, PS, Molden, J and Goedert, JJ Evidence for Concurrent Epidemics of Human Herpesvirus-8 and Human Immunodeficiency Virus Type 1 in Homosexual Men: Rates, Risk Factors, and Relationship to Kaposi's Sarcoma Journal of Infectious Diseases 1999; 180:1010-7.

Martin, J. N., Z. Amad, C. Cossen, P. K. Lam, D. H. Kedes, K. A. Page-Shafer, D. H. Osmond, and B. Forghani Use of epidemiologically well-defined subjects and existing immunofluorescence assays to calibrate a new enzyme immunoassay for human herpesvirus 8 antibodies. Journal of Clinical Microbiology. 2000, 38:696-701.

Nealon, K., W. W. Newcomb, T. R. Pray, C. S. Craik, J. C. Brown, and D. H. Kedes. Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus Results in the Formation of Multiple Capsid Species: Isolation and Molecular Characterization of A, B, and C Capsids from a Gammaherpesvirus. Journal of Virology 2001, 75:2866-2878.

Trus, B. L., J. B. Heymann, K. Nealon, N. Cheng, W. W. Newcomb, J. C. Brown, D. H. Kedes, and A. C. Steven. Capsid Structure of Kaposi's Sarcoma-Associated Herpesvirus, a Gammaherpesvirus, Compared to Those of an Alphaherpesvirus, Herpes Virus Type 1, and a Betaherpesvirus, Cytomegalovirus. Journal of Virology 2001, 75:2879-2890.

Brander C. O'Connor P. Suscovich T. Jones NG. Lee Y. Kedes D. Ganem D. Martin J. Osmond D. Southwood S. Sette A. Walker BD. Scadden DT. Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein. Journal of Infectious Diseases. 2001, 184(2):119-26,.

Brander C, Raje N, O'Connor PG, Davies F, Davis J, Chauhan D, Hideshima T, Martin J, Osmond D, Kedes DH, Walker BD, Scadden DT, Anderson KC. Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma Blood 2002, 100(2):698-700,.

Biggar, R.J., Engels, E.A., Whitby, D., Kedes, D.H., and Goedert, J.J. Antibody Reactivity to Latent and Lytic Antigens to Human Herpesvirus 8 in Longitudinally-followed Homosexual Men Journal of Infectious Diseases 2003, 187(1):12-18,.

Whitby D, Stossel A, Gamache C, Papin J, Bosch M, Smith A, Kedes DH, White G, Kennedy R, Dittmer DP Novel Kaposi's sarcoma-associated herpesvirus homolog in baboons. Journal of Virology 2003, Jul;77(14):8159-65.

Tomescu, C., Law, W.K. and Kedes, D.H. Surface downregulation of MHC Class I, PE-CAM, and ICAM-1 following de novo infection of endothelial cells with Kaposi's sarcoma-associated herpesvirus Journal of Virology, 2003, 77(17): 9669-9684.

Yu, X, C. O'Connor, I. Atanasov, B. Damania, Kedes, D.H., and Z. Hong Zhou Three-Dimensional Structure of the A, B, and C Capsids of Rhesus Monkey Rhadinovirus: Insights into Gammaherpesvirus Capsid Assembly and DNA Packing Journal of Virology 2003, 75:13182-13193.

O'Connor, C., Damania, B. and Kedes, D.H. De novo Infection with Rhesus Monkey Rhadinovirus Leads to the Accumulation of Multiple Intranuclear Capsid Species During Lytic Replication but Favors the Release of Genome-Containing Virions Journal of Virology 2003, 75:13439-13447.

Renne R, Dittmer D, Kedes D, Schmidt K, Desrosiers RC, Luciw PA, Ganem D. Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SIV-positive and SIV-negative rhesus macaques. J Med Primatol. 2004, 33(1) 1-9.

Parsons, C.H., Szomju, B. and Kedes, D.H. Susceptibility of Human Fetal Mesencyhmal Stem Cells to Kaposi's Sarcoma-associated Herpesvirus. Blood. 2004; 104(1): 2736-8.

Woodberry, T., Suscovich, T.J., Henry, L.H., Martin, J.N., Dollard, S., O'Connor, P.G., Davis, J.K., Osmond, D., Lee, T.-H., Kedes, D.H., Khatri, A., Lee, J., Walker, B.D., Scadden, D.T. and Brander, C. Impact of Kaposi Sarcoma-Associated Herpesvirus (KSHV) Burden and HIV Coinfection on the Detection of T Cell Responses to KSHV ORF73 and ORF65 Proteins. The Journal of Infectious Diseases 2005, 192: 622-629.

O'Connor, C. and Kedes, D.H. Mass Spectrometric Analyses of Purified Rhesus Monkey Rhadinovirus Reveal 33 Virion-Associated Proteins Journal of Virology 2006, 80(3):1574-1583.

[1],[2]Parsons, C.H., Adang, L.A., Overdevest, J., O'Connor, C., Camerini, D., and Kedes, D.H. KSHV targets multiple leukocyte lineages during long-term productive infection in NOD/SCID mice. J. Clin. Invest. 2006 116:1963-1973.

[3],[4]Adang, L.A., Parsons, C.H. and Kedes, D.H. Asynchronous progression through the lytic cascade and variations in intracellular viral loads revealed by high-throughput single cell analysis of KSHV infection Journal of Virology 2006, 80:10073-10082.

Adang, L.A, Tomescu, C., Law, W.K., and Kedes, D.H. Intracellular KSHV load determines early loss of immune synapse components Journal of Virology 2007, 81:5079-5090.

Binbin Deng, Christine M. O'Connor, Dean H. Kedes and Z. Hong Zhou Direct visualization of a bacteriophage-like portal in the Kaposi's sarcoma-associated herpesvirus capsid by cryo-electron tomography Journal of Virology 2007, 81:3640-3644.

Deng, B., O'Connor, C.M., Kedes, D.H. and Zhou, H.Z. Cryo-electron tomography of Kaposi's sarcoma-associated herpesvirus capsids reveals dynamic scaffolding structures essential to capsid assembly and maturation Journal of Structural Biology 2008, 161:419-427.

Wong Hoi Hui, Sanket Shah, Christine M. O'Connor, Ivo Atanasov, Michael B. Sherman, Dean H. Kedes and Z. Hong Zhou Deciphering molecular interactions and assembly mechanisms of a tumor herpesvirus capsid (under review).

Nichols, L., Adang, L.A. and Kedes, D.H. The transplant immunosuppressant drug, rapamycin, inhibits reactivation of KSHV (manuscript under revision).

INVITED Review and Chapters

Kedes, DH and Kedes, LH Molecular Genetics and its Application to Understanding Cardiovascular Disease in Molecular Genetics and Gene Therapy of Cardiovascular Diseases, Steve Mockrin, ed. Marcel Dekker, Inc New York Dec. 1995.

O'Connor, C. and Kedes, D.H. Rhesus monkey rhadinovirus: A model for the study of KSHV. In KSHV, ed. Boshoff, C. and Weiss, R. Springer Press, CTMI 312:43-69 New York 2006.

[1] Featured in "Editor's Pick" section

[2] Article selected for inclusion in Faculty of 1000, Biology

[3] Featured in Journal's "Spotlight" section

[4] Article selected for inclusion in Faculty of 1000, Biology