Basic Research Publications from the TCV Surgery Lab:
Ellman PI, Reece TB, Law MG, Gazoni LM, Singh R, Laubach VE*, Tribble CG, and Kron IL. Adenosine A2A activation attenuates non-tranplantation lung reperfusion injury. J Surg Res (In Press)
Gazoni LM, Laubach VE, Mulloy DP, Bellizzi A, Unger EB, Ellman PI, Lisle TC, Linden J, and Kron IL. Timing is everything. Additive protection against lung ischemia reperfusion injury by adenosine A2A receptor activation prior to procurement and during reperfusion. J Thorac Cardiovasc Surg 135:156-165, 2008. [PDF]
Fernandez LG, Mehta CK, Kron IL, and Laubach VE. Re-initiation of compensatory lung growth after subsequent lung resection. J Thorac Cardiovasc Surg 134:1300-1305, 2007. [PDF]
Sharma AK, Fernandez LG, Awad AS, Kron IL, and Laubach VE.
Proinflammatory response of alveolar epithelial cells is enhanced by
alveolar macrophage-produced TNF-alpha during pulmonary
ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 293:105-113, 2007. [PDF]
Gazoni LM, Tribble CG, Zhao MQ, Unger EB, Farrar RA, Ellman PI, Fernandez LG, Laubach VE, and Kron IL. Pulmonary macrophage inhibition and inhaled nitric oxide attenuate lung ischemia reperfusion injury. Ann Thorac Surg 84:247-253, 2007. [PDF]
Fernandez LG, Le Cras TD, Ruiz M, Glover DK, Kron IL, and Laubach VE. Differential vascular growth in postpneumonectomy compensatory lung growth. J Thorac Cardiovasc Surg 133:309-316, 2007. [PDF]
Zhao M, Fernandez LG, Doctor A, Sharma AK, Zarbock A, Tribble CG, Kron IL, and Laubach VE. Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 291:L1018-1026, 2006. [PDF]
Singh RR, Laubach VE, Ellman PI, Reece TB, Unger E, Kron IL, and Tribble CG. Attenuation of lung reperfusion injury by modified ventilation and reperfusion techniques. J Heart Lung Transplant 25:1467-1473, 2006. [PDF]
Reece TB, Okonkwo DO, Ellman PI, Maxey TS, Tache-Leon C, Warren PS, Laurent JJ, Linden J, Kron IL, Tribble CG, and Kern JA. Comparison of systemic and retrograde delivery of adenosine A2A agonist for attenuation of spinal cord injury after thoracic aortic cross-clamping. Ann Thorac Surg 81:902-909, 2006. [PDF]
Reece TB, Kron IL, Okonkwo DO, Laurent JJ, Tache-Leon C, Maxey TS, Ellman PI, Linden J, Tribble CG, and Kern JA. Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism. J Vasc Surg 44:392-397, 2006. [PDF]
Okonkwo DO, Reece TB, Laurent JJ, Hawkins AS, Ellman PI, Linden J, Kron IL, Tribble CG, Stone JR, and Kern JA. A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbits. J Neurosurg Spine 4:64-70, 2006. [PDF]
Maxey TS, Fernandez LG, Reece TB, Keeling WB, Kron IL, and Laubach VE. Endothelial nitric oxide synthase is essential for postpneumonectomy compensatory vasodilation. Ann Thorac Surg 81:1234-1238, 2006. [PDF]
Reece TB, Laubach VE, Tribble CG, Maxey TS, Ellman PI, Warren PS, Schulman AM, Linden J, Kern JA, and Kron IL. Adenosine A2A receptor agonist improves cardiac dysfunction from pulmonary ischemia-reperfusion injury. Ann Thorac Surg 79:1189-1195, 2005. [PDF]
Reece TB, Ellman PI, Maxey TS, Crosby IK, Warren PS, Chong TW, LeGallo RD, Linden J, Kern JA, Tribble CG, and Kron IL. Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantation. J Thorac Cardiovasc Surg 129:1137-1143, 2005. [PDF]
Patel MR, Laubach VE, Tribble CG, and Kron IL. Hyperinflation during lung preservation and increased reperfusion injury. J Surg Res 123:134-138, 2005. [PDF]
Li D, Fernandez LG, Dodd-o J, Langer J, Wang D, and Laubach VE. Upregulation of hypoxia-induced mitogenic factor in compensatory lung growth after pneumonectomy. Am J Respir Cell Mol Biol 32:185-191, 2005. [PDF]
Le Cras TD, Fernandez LG, Pastura PA, and Laubach VE. Vascular growth and remodeling in compensatory lung growth following right lobectomy. J Appl Physiol 98:1140-1148, 2005. [PDF]
Ellman PI, Alvis JS, Tache-Leon C, Singh R, Reece TB, Kern JA, Tribble CG, and Kron IL. Hyperoxic ventilation exacerbates lung reperfusion injury. J Thorac Cardiovasc Surg 130:1440, 2005. [PDF]
Reece TB, Okonkwo DO, Ellman PI, Warren PS, Smith RL, Hawkins AS, Linden J, Kron IL, Tribble CG, and Kern JA. The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation. J Thorac Cardiovasc Surg 128:925-932, 2004. [PDF]
Reece TB, Davis JD, Okonkwo DO, Maxey TS, Ellman PI, Li X, Linden J, Tribble CG, Kron IL, and Kern JA. Adenosine A2A analogue reduces long-term neurologic injury after blunt spinal trauma. J Surg Res 121:130-134, 2004. [PDF]
Maxey TS, Enelow RI, Gaston B, Kron IL, Laubach VE, and Doctor A. Tumor necrosis factor-alpha from resident lung cells is a key initiating factor in pulmonary ischemia-reperfusion injury. J Thorac Cardiovasc Surg 127:541-547, 2004. [PDF]
Long SM, Laubach VE, Tribble CG, Kaza AK, Fiser SM, Cassada DC, Kern JA, and Kron IL. Pyrrolidine dithiocarbamate reduces lung reperfusion injury. J Surg Res 112:12-18, 2003. [PDF]
Leuwerke SM, Kaza AK, Tribble CG, Kron IL, and Laubach VE. Inhibition of compensatory lung growth in endothelial nitric oxide synthase-deficient mice. Am J Physiol Lung Cell Mol Physiol 282:L1272-1278, 2002. [PDF]
Kaza AK, Kron IL, Leuwerke SM, Tribble CG, and Laubach VE. Keratinocyte growth factor enhances post-pneumonectomy lung growth by alveolar proliferation. Circulation 106:I120-124, 2002. [PDF]
Kaza AK, Cope JT, Fiser SM, Long SM, Kern JA, Tribble CG, Kron IL, and Laubach VE. Contrasting natures of lung growth after transplantation and lobectomy. J Thorac Cardiovasc Surg 123:288-294, 2002. [PDF]
Fiser SM, Tribble CG, Kaza AK, Long SM, Kern JA, Cassada DC, Linden J, Rieger J, Laubach VE, Matisoff A, and Kron IL. Adenosine A2A receptor activation decreases reperfusion injury associated with high-flow reperfusion. J Thorac Cardiovasc Surg 124:973-978, 2002. [PDF]
Fiser SM, Kron IL, Long SM, Kaza AK, Kern JA, Cassada DC, Laubach VE, and Tribble CG. Controlled perfusion decreases reperfusion injury after high-flow reperfusion. J Heart Lung Transplant 21:687-691, 2002. [PDF]
Cassada DC, Tribble CG, Young JS, Gangemi JJ, Gohari AR, Butler PD, Rieger JM, Kron IL, Linden J, and Kern JA. Adenosine A2A analogue improves neurologic outcome after spinal cord trauma in the rabbit. J Trauma 53:225-229, 2002. [PDF]
Cassada DC, Tribble CG, Long SM, Laubach VE, Kaza AK, Linden J, Nguyen BN, Rieger JM, Fiser SM, Kron IL, and Kern JA. Adenosine A2A analogue ATL-146e reduces systemic tumor necrosing factor-alpha and spinal cord capillary platelet-endothelial cell adhesion molecule-1 expression after spinal cord ischemia. J Vasc Surg 35:994-998, 2002. [PDF]
Cassada DC, Tribble CG, Long SM, Kaza AK, Linden J, Rieger JM, Rosin D, Kron IL, and Kern JA. Adenosine A2A agonist reduces paralysis after spinal cord ischemia: correlation with A2A receptor expression on motor neurons. Ann Thorac Surg 74:846-849, 2002. [PDF]
Kaza AK, Kron IL, Long SM, Fiser SM, Stevens PM, Kern JA, Tribble CG, and Laubach VE. Epidermal growth factor receptor up-regulation is associated with lung growth after lobectomy. Ann Thorac Surg 72:380-385, 2001. [PDF]
Kaza AK, Kron IL, Kern JA, Long SM, Fiser SM, Nguyen RP, Tribble CG, and Laubach VE. Retinoic acid enhances lung growth after pneumonectomy. Ann Thorac Surg 71:1645-1650, 2001. [PDF]
Fiser SM, Tribble CG, Long SM, Kaza AK, Kern JA, and Kron IL. Pulmonary macrophages are involved in reperfusion injury after lung transplantation. Ann Thorac Surg 71:1134-1138, 2001. [PDF]
Fiser SM, Tribble CG, Long SM, Kaza AK, Cope JT, Laubach VE, Kern JA, and Kron IL. Lung transplant reperfusion injury involves pulmonary macrophages and circulating leukocytes in a biphasic response. J Thorac Cardiovasc Surg 121:1069-1075, 2001. [PDF]
Cassada DC, Tribble CG, Laubach VE, Nguyen BN, Rieger JM, Linden J, Kaza AK, Long SM, Kron IL, and Kern JA. An adenosine A2A agonist, ATL-146e, reduces paralysis and apoptosis during rabbit spinal cord reperfusion. J Vasc Surg 34:482-488, 2001. [PDF]
Cassada DC, Tribble CG, Kaza AK, Fiser SM, Long SM, Linden J, Rieger JM, Kron IL, and Kern JA. Adenosine analogue reduces spinal cord reperfusion injury in a time-dependent fashion. Surgery 130:230-235, 2001. [PDF]
Cassada DC, Gangemi JJ, Rieger JM, Linden J, Kaza AK, Long SM, Kron IL, Tribble CG, and Kern JA. Systemic adenosine A2A agonist ameliorates ischemic reperfusion injury in the rabbit spinal cord. Ann Thorac Surg 72:1245-1250, 2001. [PDF]
Young JS, Rayhrer CS, Edmisten TD, Cephas GA, Tribble CG, and Kron IL. Sodium nitroprusside mitigates oleic acid-induced acute lung injury. Ann Thorac Surg 69:224-227, 2000. [PDF]
Ross SD, Kron IL, Gangemi JJ, Shockey KS, Stoler M, Kern JA, Tribble CG, and Laubach VE. Attenuation of lung reperfusion injury after transplantation using an inhibitor of nuclear factor-kappaB. Am J Physiol Lung Cell Mol Physiol 279:L528-536, 2000. [PDF]
Ross SD, Kern JA, Gangemi JJ, St Laurent CR, Shockey KS, Kron IL, and Tribble CG. Hypothermic retrograde venous perfusion with adenosine cools the spinal cord and reduces the risk of paraplegia after thoracic aortic clamping. J Thorac Cardiovasc Surg 119:588-595, 2000. [PDF]
Quinlan TR, Li D, Laubach VE, Shesely EG, Zhou N, and Johns RA. eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol 279:L641-650, 2000. [PDF]
Parrino PE, Kron IL, Ross SD, Shockey KS, Fisher MJ, Gaughen JR, Jr., Kallmes DF, Kern JA, and Tribble CG. Retrograde venous perfusion with hypothermic saline and adenosine for protection of the ischemic spinal cord. J Vasc Surg 32:171-178, 2000. [PDF]
Mathias MA, Tribble CG, Dietz JF, Nguyen RP, Shockey KS, Kern JA, and Kron IL. Aprotinin improves pulmonary function during reperfusion in an isolated lung model. Ann Thorac Surg 70:1671-1674, 2000. [PDF]
Kaza AK, Laubach VE, Kern JA, Long SM, Fiser SM, Tepper JA, Nguyen RP, Shockey KS, Tribble CG, and Kron IL. Epidermal growth factor augments postpneumonectomy lung growth. J Thorac Cardiovasc Surg 120:916-921, 2000. [PDF]
Hannan RL, John MC, Kouretas PC, Hack BD, Matherne GP, and Laubach VE. Deletion of endothelial nitric oxide synthase exacerbates myocardial stunning in an isolated mouse heart model. J Surg Res 93:127-132, 2000. [PDF]
Gangemi JJ, Kern JA, Ross SD, Shockey KS, Kron IL, and Tribble CG. Retrograde perfusion with a sodium channel antagonist provides ischemic spinal cord protection. Ann Thorac Surg 69:1744-1748, 2000. [PDF]
Ross SD, Tribble CG, Linden J, Gangemi JJ, Lanpher BC, Wang AY, and Kron IL. Selective adenosine-A2A activation reduces lung reperfusion injury following transplantation. J Heart Lung Transplant 18:994-1002, 1999. [PDF]
Ross SD, Tribble CG, Gaughen JR, Jr., Shockey KS, Parrino PE, and Kron IL. Reduced neutrophil infiltration protects against lung reperfusion injury after transplantation. Ann Thorac Surg 67:1428-1433, 1999. [PDF]
Parrino PE, Kron IL, Ross SD, Shockey KS, Fisher MJ, Gaughen JR, Jr., Kern JA, and Tribble CG. Spinal cord protection during aortic cross-clamping using retrograde venous perfusion. Ann Thorac Surg 67:1589-1594, 1999. [PDF]
Parrino PE, Laubach VE, Gaughen JR, Jr., Shockey KS, Wattsman TA, King RC, Tribble CG, and Kron IL. Inhibition of inducible nitric oxide synthase after myocardial ischemia increases coronary flow. Ann Thorac Surg 66:733-739, 1998. [PDF]
Laubach VE, Foley PL, Shockey KS, Tribble CG, and Kron IL. Protective roles of nitric oxide and testosterone in endotoxemia: evidence from NOS-2-deficient mice. Am J Physiol Lung Cell Mol Physiol 275:H2211-2218, 1998. [PDF]
King RC, Laubach VE, Kanithanon RC, Kron AM, Parrino PE, Shockey KS, Tribble CG, and Kron IL. Preservation with 8-bromo-cyclic GMP improves pulmonary function after prolonged ischemia. Ann Thorac Surg 66:1732-1738, 1998. [PDF]
Laubach VE, Zhang CX, Russell SW, Murphy WJ, and Sherman PA. Analysis of expression and promoter function of the human inducible nitric oxide synthase gene in DLD-1 cells and monkey hepatocytes. Biochim Biophys Acta 1351:287-295, 1997. [PDF]
King RC, Binns OA, Kanithanon RC, Parrino PE, Reece TB, Maliszewskyj JD, Shockey KS, Tribble CG, and Kron IL. Acellular low-potassium dextran preserves pulmonary function after 48 hours of ischemia. Ann Thorac Surg 64:795-800, 1997. [PDF]
King RC, Binns OA, Kanithanon RC, Cope JT, Chun RL, Shockey KS, Tribble CG, and Kron IL. Low-dose sodium nitroprusside reduces pulmonary reperfusion injury. Ann Thorac Surg 63:1398-1404, 1997. [PDF]
Cope JT, Banks D, Laubach VE, Binns OA, King RC, Richardson RM, Shockey KS, Tribble CG, and Kron IL. Sodium nitroprusside exacerbates myocardial ischemia-reperfusion injury. Ann Thorac Surg 64:1656-1659, 1997. [PDF]
Binns OA, DeLima NF, Buchanan SA, Lopes MB, Cope JT, Marek CA, King RC, Laubach VE, Tribble CG, and Kron IL. Mature pulmonary lobar transplants grow in an immature environment. J Thorac Cardiovasc Surg 114:186-194, 1997. [PDF]
Binns OA, DeLima NF, Buchanan SA, King RC, Cope JT, Maliszewskyj JD, Tribble CG, and Kron IL. Use of over-sized mature pulmonary lower lobe grafts results in superior pulmonary function. Ann Thorac Surg 64:307-312, 1997. [PDF]
Cope JT, Mauney MC, Banks D, Binns OA, Moore CL, Rentz JJ, Shockey KS, King RC, Kron IL, and Tribble CG. Intravenous phenyllephrine preconditioning of cardiac grafts from non-heart-beating donors. Ann Thorac Surg 63:1664-1668, 1997. [PDF]
Thies SD, Corbin RS, Goff CD, Binns OA, Buchanan SA, Shockey KS, Frierson HF, Jr., Young JS, Tribble CG, and Kron IL. Thromboxane receptor blockade improves oxygenation in an experimental model of acute lung injury. Ann Thorac Surg 61:1453-1457, 1996. [PDF]
DeLima NF, Binns OA, Buchanan SA, Mauney MC, Cope JT, Shockey KS, Tribble CG, and Kron IL. Euro-Collins solution exacerbates lung injury in the setting of high-flow reperfusion. J Thorac Cardiovasc Surg 112:111-116, 1996. [PDF]
DeLima NF, Binns OA, Buchanan SA, Cope JT, Mauney MC, Shockey KS, Tribble CG, and Kron IL. Low-potassium solution for lung preservation in the setting of high-flow reperfusion. Ann Thorac Surg 61:973-976, 1996. [PDF]
Cope JT, Mauney MC, Banks D, Binns OA, De Lima NF, Buchanan SA, Shockey KS, Wilson SW, Kron IL, and Tribble CG. Controlled reperfusion of cardiac grafts from non-heart-beating donors. Ann Thorac Surg 62:1418-1423, 1996. [PDF]
Mauney MC, Cope JT, Binns OAR, King RC, Shockey KS, Buchanan SA, Wilson SW, Cogbill J, Kron IL, and Tribble CG. Non-heart-beating donors: A model of thoracic allograft injury. Ann Thorac Surg 62:54-62, 1996. [PDF]
Buchanan SA, Mauney MC, Parekh VI, DeLima NF, Binns OA, Cope JT, Shockey KS, Tribble CG, and Kron IL. Intratracheal surfactant administration preserves airway compliance during lung reperfusion. Ann Thorac Surg 62:1617-1621, 1996. [PDF]
Buchanan SA, Mauney MC, deLima NF, Binns OA, Cope JS, Shockey KS, Gordon SG, Erwin MB, Sutherland G, Kron IL, and Tribble CG. Enhanced isolated lung function after ischemia with anti-intercellular adhesion molecule antibody. J Thorac Cardiovasc Surg 111:941-947, 1996. [PDF]
Binns OA, DeLima NF, Buchanan SA, Mauney MC, Cope JT, Thies SD, Shockey KS, Tribble CG, and Kron IL. Neutrophil endopeptidase inhibitor improves pulmonary function during reperfusion after eighteen-hour preservation. J Thorac Cardiovasc Surg 112:607-613, 1996. [PDF]
Binns OA, DeLima NF, Buchanan SA, Cope JT, King RC, Marek CA, Shockey KS, Tribble CG, and Kron IL. Both blood and crystalloid-based extracellular solutions are superior to intracellular solutions for lung preservation. J Thorac Cardiovasc Surg 112:1515-1521, 1996. [PDF]
Langenburg SE, Blackbourne LH, Buchanan SA, Mauney MC, Kim SS, Sinclair KN, Kern JA, Teja SS, Tribble CG, and Kron IL. Compensatory growth of porcine right lungs after chronic rejection of transplanted left lungs. Ann Thorac Surg 59:28-32, 1995. [PDF]
Kern JA, Tribble CG, Zografakis JG, Cassada DC, Chan BB, and Kron IL. Analysis of airway function of immature whole lung transplants versus mature lobar transplants. Ann Thorac Surg 57:1089-1094, 1994.
Herold JA, Kron IL, Langenburg SE, Blackbourne LH, and Tribble CG. Complete prevention of postischemic spinal cord injury by means of regional infusion with hypothermic saline and adenosine. J Thorac Cardiovasc Surg 107:536-541; discussion 541-532, 1994.
Seibel PS, Theodore P, Kron IL, and Tribble CG. Regional adenosine attenuates postischemic spinal cord injury. J Vasc Surg 18:153-158; discussion 158-160, 1993.
Kern JA, Kron IL, Flanagan TL, Binns OA, Scott WW, Chan BB, Zografakis JG, and Tribble CG. Denervation of the immature porcine lung impairs normal airway development. J Heart Lung Transplant 12:34-40, 1993.
Francel PC, Long BA, Malik JM, Tribble C, Jane JA, and Kron IL. Limiting ischemic spinal cord injury using a free radical scavenger 21-aminosteroid and/or cerebrospinal fluid drainage. J Neurosurg 79:742-751, 1993.
Chan BB, Kron IL, Flanagan TL, Kern JA, Hobson CE, and Tribble CG. Impairment of vascular endothelial function by high-potassium storage solutions. Ann Thorac Surg 55:940-945, 1993.
Kern JA, Tribble CG, Flanagan TL, Chan BB, Scott WW, Cassada DC, and Kron IL. Growth potential of porcine reduced-size mature pulmonary lobar transplants. J Thorac Cardiovasc Surg 104:1329-1332, 1992.
Kern JA, Tribble CG, Chan BB, Flanagan TL, and Kron IL. Reduced-size porcine lung transplantation: long-term studies of pulmonary vascular resistance. Ann Thorac Surg 53:583-588, 1992.
Chan BB, Kern JA, Flanagan TL, Kron IL, and Tribble CG. Effects of in vivo cyclosporine administration on endothelium-dependent responses in isolated vascular rings. Circulation 86:II295-299, 1992. [PDF]
Ruiz AJ, Chan BB, Meyerhoefer TA, Buck DR, Farley PC, Flanagan TL, and Kron IL. Effects of ischemia and hemoglobin on vascular function in isolated rabbit aortas. J Vasc Surg 13:487-490, 1991.
Hobson CE, Teague WG, Tribble CG, Mills SE, Chan B, Agee J, Flanagan TL, and Kron IL. Denervation of transplanted porcine lung causes airway obstruction. Ann Thorac Surg 52:1295-1299, 1991.
Agee JM, Flanagan T, Blackbourne LH, Kron IL, and Tribble CG. Reducing postischemic paraplegia using conjugated superoxide dismutase. Ann Thorac Surg 51:911-914, 1991.