Animal Models used in the TCV Research Lab
In our lab, Residents, Postdocs and students utilize relevant animal models of lung injury, lung preservation, transplantation, growth and injury. These models include:-
Pneumonectomy (mice & rats) and lobectomy (rats and swine)
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Cardiopulmonary bypass in rats
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Isolated, blood-perfused rabbit lung model
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Isolated, buffer-perfused mouse lung system
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Mouse in vivo hilar clamp model of lung ischemia-reperfusion
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Spinal cord blunt trauma model in rabbits and mice
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Spinal cord ischemia-reprefusion injury in rabbits and pigs
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Tracheal transplant in mice
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Heterotopic heart transplant in mice
Pete Ellman with our isolated, blood-perfused rabbit lung model used to study lung preservation and ischemia-reperfusion injury. |
Isolated, blood-perfused rabbit lungs. |
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We use an isolated, buffer-perfused mouse lung model to measure lung function in various genetic mouse models. Click on the video below to see this model in action. Note that the lungs are white because of the buffer perfusion.
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We also utilize an in vivo mouse model of lung ischemia-reperfusion injury via hilar clamping.
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