David R. Jones, M.D.
Associate Professor of Surgery
Chief, General Thoracic Surgery
Surgical Director, Lung Transplantation Program
Division of Thoracic and Cardiovascular Surgery
Dr. David Jones


Clinical Interests
                        Lung Cancer, Surgical Oncology
                        Esophageal Cancer
                        GERD, Achalasia, Hiatal Hernias
                        Minimally-invasive Thoracic Surgery
                        Mediastinal Diseases/Tumors
                        Benign Diseases of the Lung
                        Chest Wall Tumors and Congenital Defects
                        Lung Transplantation
                        Chronic Obstructive Pulmonary Disease

 
Research Interests
  • Anti-Apoptotic Signal Transduction Pathways in Lung and Esophageal Cancers
  • Sensitizing Lung Cancers to Chemotherapy
  • Translational Oncology Research With Novel Biologic Agents

Medical Education
  West Virginia University M.D. 1989

Postgraduate Medical Education
West Virginia University - General Surgery 1989-'95
University of North Carolina at Chapel Hill - Thoracic Surgery 1995-'98
Post-Doctoral Fellow Molecular Biology – UNC-Chapel Hill 1998-‘99

Licensure
Virginia
North Carolina

Board Certification

American Board of Surgery
American Board of Thoracic Surgery

Professional Societies (selected):
         American Association of Thoracic Surgery
         Society of Thoracic Surgeons
         Society of University Surgeons
         American Association of Cancer Research
         General Thoracic Surgery Club
         American College of Chest Physicians
         American College of Surgeons
         International Association for the Study of Lung Cancer
         Southern Thoracic Surgical Association
         General Thoracic Surgery Biology Club
         International Society of Heart and Lung Transplantation
         Association for Academic Surgery
         American Thoracic Society
         Virginia Surgical Society
         Nathan S. Womack Surgical Society
         Muller-Jones Surgical Society

Recent Publications (selected):

  1. Jones DR, Broad RM, Madrid LD, Baldwin Jr. AS, Mayo MW.  Inhibition of NF-kB sensitizes non-small cell lung cancer to chemotherapy-induced apoptosis.  Ann Thorac Surg 2000;70:930-937.
  2. El-Rifai W, Frierson HF, Moskaluk CA, Harper JC, Petroni G, Bissonette E, Jones DR , Knuutila, Powell SM.  Genetic differences between adenocarcinomas arising in Barrett’s esophagus and gastric mucosa.  Gastroenterol 2001;121:592-8.
  3. Fiser SM, Kron IL, Long SM, Kaza AK, Kern JA, Cassada DC, Jones DR , Robbins MC, Tribble CG.  Influence of graft ischemic time on outcomes following lung transplantation.  J Heart Lung Transplant 2001; 20:1291-6.
  4. Jones DR , Broad, Parsons SJ, Mayo MW. Inhibition of NF-B chemosensitizes non-small cell lung cancer via cytochrome c release and caspase activation. J Thorac Cardiovasc Surg 2002; 123:310-7.
  5. Mayo MW, Madrid LV , Westerheide SD , Jones DR , Yuan XJ, Baldwin AS , Whang YE. PTEN blocks TNF-induced NF-kB-dependent transcription by inhibiting the transactivation potential of the p65 subunit. J Biol Chem 2002;277:11116-25.
  6. Kaza AK, Dietz JF, Kern JA, Jones DR , Robbins MK, Fiser SM, Long SM, Bergin JD, Kron IL, Tribble CG. Coronary risk stratification in patients with end-stage lung disease. J Heart Lung Transplant 2002;21:334-9.
  7. Jones DR , Stiles BM, Denlinger CE, Antippa P, Daniel TM. Pulmonary segmentectomy: results and complications. Ann Thorac Surg 2003;76:343-9.
  8. Detterbeck FC, Jones DR , Kernstine KH, Naunheim KS . ACCP Guidelines for lung cancer patients: Special treatment issues. Chest 2003;123:244-258S.
  9. Mayo MW, Denlinger CE, Broad RM, Yeung F, Reilly ET, Shi Y, Jones DR .  Ineffectiveness of HDAC inhibitors to induce apoptosis involves the transcriptional activation of NF-kB through the Akt pathway. J Biol Chem 2003;278:18980-9.
  10. Denlinger CE, Keller MD, Mayo MW, Broad RM, Jones DR . Combined histone deacetylation and proteasome inhibition in non-small cell lung cancer. J Thorac Cardiovasc Surg 2003;127:1078-86.
  11. Daniel TM, Altes TA, Williams MB, Jones DR , Stolin AV, Gay SB. A Novel Technique for Localization and Excisional Biopsy of Small or Ill-defined Pulmonary Lesions Ann Thorac Surg 2004;77:1756-62.
  12. Denlinger CE, Rundall BK, Jones DR . Modulation of anti-apoptotic cell-signaling pathways in non-small cell lung cancer:  The role of NF-kB.  Semin Thorac Cardiovasc Surg 2004;16:28-39.
  13. Denlinger CE, Rundall BK, Kellers MD, Jones DR . Proteasome inhibition sensitizes non-small cell lung cancer to gemcitabine-induced apoptosis.   Ann Thorac Surg 2004;78:1207-14.
  14. Yeung F, Hoberg JE, Ramsey C, Keller M, Jones DR , Frye RA, Mayo MW. Modulation of NF-kB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO 2004;23:2369-80.
  15. Denlinger CE, Rundall BK, Jones DR .  Proteasome inhibition sensitizes NSCLC to HDAC inhibitor-induced apoptosis through the generation of reactive oxygen species.  J Thorac Cardiovasc Surg 2004:128:480-8.
  16. Rundall BK, Denlinger CE, Parrino GP, Foley EF, Jones DR . Gastrointestinal reconstruction following laparoscopic gastric bypass surgery complicated by gastric pouch necrosis. J Gastrointest Surg 2005 (in press).
  17. Allen MS, Darling GE, Pechet TVT, Mitchell JD, Herndon II JE, Landreneau RJ, Inculet RI , Jones DR , Meyers BF, Putnam JB, Rusch VW and the ACOSOG Z0030 study group. Morbidity and Mortality of Major Pulmonary Resections in Patients With Early Stage Lung Cancer:  Initial Results of the Randomized, Prospective ACOSOG Z0030 Trial. Ann Thorac Surg 2005 (in press).
  18. Jones DR , Daniel TM, Denlinger CE, Rundall BK, Smolkin ME. Stage IB non-small cell lung cancers: Are they all the same? Ann Thorac Surg 2005 (in press).
  19. Rundall BK, Denlinger CE, Jones DR. Suberoylanilide hydroxamic acid combined with gemcitabine enhances apoptosis in non-small cell lung cancer. Surgery 2005 (in press).
  20. Denlinger CE, Rundall BK, Jones DR . Inhibition of PI3K/Akt and histone deacetylase activity induces apoptosis in non-small cell lung cancer in vitro and in vivo. J Thorac Cardiovasc Surg 2005 (in press).

 

Recent Book Chapters (selected):

  1. Buchanan SA, Jones DR .  Management of chest wall trauma.  Current Surgical Therapy.  Cameron JL ed., Mosby, 2001.
  2. Graeber GM, Jones DR , Pairolero PC.  Primary neoplasms.  In:  Pearson FG, Deslauries J, Ginsberg RJ, Hiebert CA, McNeally MF, and Urschel HG Jr. (eds).  Thoracic Surgery.  New York :  Churchill Livingstone, 2001.
  3. Jones DR .  Anterior Mediastinal Masses.  Current Therapy in Thoracic and Cardiovascular Surgery. Yang S. and Cameron D., eds. Harcourt Health Sciences, Philadelphia , PA , 2004.
  4. Mayo MW and Jones DR . Dynamic regulation of NF-kB transcriptional activity via recruitment of co-activator and co-repressor complexes. Mechanisms of signal transduction and inducible gene expression. Research Signpost Publisher. Note: This is an invited book chapter. 2004.
  5. Jones DR . Biology and Epidemiology of Lung Cancer. In: Pearson, Patterson GA , Cooper, Deslauriers J, Lerut T, Luketich J, and Rice TW. Pearson’s Textbook of Thoracic-Esophageal Surgery. New York :  Churchill Livingstone, 2006.
  6. Jones DR . Chest wall resection and reconstruction. In: Sugarbaker DS, Bueno R, Zellos L (eds.). Adult Chest Surgery: Concepts and Procedures. McCraw-Hill, Inc., 2006.

Address
Department of Surgery
PO Box 800679
Charlottesville , Virginia 22908-0679

Email
djones@virginia.edu

Telephone
434-243-6443

Fax
434-982-1026