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Vesna  Jevtovic-Todorovic
Degree(s): MD/PhD
Graduate School: University of Belgrade; Univ of Illinois, Chicago
Primary Appointment: Professor, Anesthesiology
Research Interests:
Mechanisms by which anesthetic drugs interact with neurotransmitter systems in the central nervous system to produce pharmacological and toxicological effects.
Email Address: vj3w@virginia.edu
Biomedical Sciences Graduate Program(s)
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    • Research Description

    Broadly, my research interests focus on mechanisms by which anesthetic drugs interact with neurotransmitter systems in the central nervous system to produce both pharmacological and toxicological effects. My primary interests thus far have centered on the identification and characterization of neurotoxic properties of commonly used intravenous and inhalational anesthetics with special emphasis on NMDA antagonist class of general anesthetics. It had extended to include several studies that have looked at the pharmacological ways of protection against this type of neurotoxicity. This research is federally funded by NIA/NIH. Another important aspect of my research is focused on pathophysiology and pharmacology of the neuropathic pain using whole animal models and variety of neurobehavioral tests. This research is federally funded by NIDA/NIH.

    Selected Publications
  • Jevtovic-Todorovic V, Benshoff N, Olney JW: Ketamine potentiates cerebrocortical damage induced by the common anesthetic agent nitrous oxide in adult rats. Br J Pharm, 2000; 130: 1692-1698.
  • Jevtovic-Todorovic V,Wozniak DW, Benshoff ND, Olney JW: Comparative evaluation of the neurotoxic properties of ketamine and nitrous oxide. Brain Res, 2001; 895: 264-267.
  • Jevtovic-Todorovic V, Wozniak DW, Powell S, Olney JW. Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in rat posterior cingulate/retrosplenial cortex. Brain Res, 2001; 913: 185-189.
  • Jevtovic-Todorovic V, Wozniak DF, Nardi A, Powell S, Olney JW. Clonidine potentiates the neuropathic pain relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effects. Brain Res 1998;781:202-211
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    Contact Information
      Office Address: PO Box 800710 Medical School/ Steele Wing, 4751, 
      Office Phone: +1 434-924-2283
      Fax Phone: +1 434-982-0019

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