Graduate School: National Institute of Immunology, New Delhi
Primary Appointment: Associate Professor, Medicine, Nephrology
Activation of Innate and Adaptive Immunity by Microbiota and it's role in autoimmune disorders.
Email Address: usd7w@Virginia.EDU
Biomedical Sciences Graduate Program(s)
My laboratory is interested in investigating pathogenetic mechanisms of rheumatic autoimmune disorders, Systemic Lupus Erythematosus and Sjögren’s syndrome. While lupus is a multi organ disorder involving kidneys, skin, lungs and heart; Sjögren’s syndrome mainly affects the exocrine glands causing the dry eye and dry mouth symptoms. A common feature of both diseases is activation of self-reactive T and B cells, and generation of anti-nuclear autoantibodies. Recent literature clearly indicates that normal microbiota shapes an individuals immune repertoire. Currently the major emphasis of our research is on understanding how oral and gut microbiota contribute towards the initiation and amplification of autoimmune responses in Lupus and Sjögren’s syndrome. In addition to basic research, my laboratory also has a strong translational focus. In this regard, we are exploring the feasibility of therapeutic agents targeting GPCRs for treatment of autoimmunity and restoration organ function.
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