Medical Students 
Graduate Medical Education
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Sheila
E.
Crowe
Degree(s): MD Graduate School: McMaster University Primary Appointment: Professor, Medicine, Gastroenterology and Hepatology Research Interests: Immune-epithelial interactions in mucosal inflammation Email Address: scrowe@virginia.edu |
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Research Description Currently, Dr. Crowe is pursuing two main projects. The first project is investigating the mechanisms whereby oxidative stress regulates the expression of genes in gastric epithelial cells during infection with H. pylori. These studies entail a characterization of the role of AP endonuclease in redox-sensitive expression of IL-8 and other genes that control inflammation. In the second project, Dr. Crowe is using mouse models of gastric cancer to study the impact of inflammation and oxidative stress in the control of epithelial cell growth and differentiation. This model also has relevance to the pathogenesis of cancer associated with other forms of inflammation including ulcerative colitis and celiac disease. Selected Publications Intranet Profile [To add/update Intranet profile information, read these instructions.]
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