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Mark  J.  Jameson
Degree(s): MD/PhD
Graduate School: Medical University of South Carolina
Primary Appointment: Assistant Professor, Otolaryngology
Research Interests:
Involvement of growth factors and resistance to chemotherapy/targeted therapy in squamous cell carcinoma of the head and neck.
Email Address: mjj4e@virginia.edu
Research Description

My laboratory conducts basic science research on the involvement of growth factors in cancer.  Although dysregulation of growth factor systems has been implicated in a variety of cancers, our primary focus is squamous cell carcinoma of the head and neck, which affects the mucosal surfaces of the upper aerodigestive tract.  Our main goals involve: (1) identifying the mechanism by which the insulin-like growth factor-1 receptor (IGF-1R) and other growth factor receptors can confer resistance to targeted therapy with anti-epidermal growth factor receptor (EGFR) agents; (2) determining the benefit of inhibiting additional growth factor receptors and/or downstream signaling molecules to increase the therapeutic efficacy of targeted anti-EGFR agents; and (3) discovering methods to predict the susceptibility of a given tumor to targeted therapy with anti-EGFR agents or with combinations of multiple targeted agents.  To address these issues, we study cell lines, xenograft models, and human tumor samples using a variety of current and emerging methodologies.

Student/Resident Rotations:
The lab welcomes students or residents interested in focused short-term projects related to our overall interests and goals.  These projects provide the student or resident an excellent opportunity to experience the process of testing a scientific hypothesis and to develop or refine technical abilities in bench research.  In previous years, two medical students involved in the Medical Student Summer Research Program (MSSRP) have worked in the lab and gone on to win awards at the annual Medical Student Research Day.

Selected Publications
  • Kibbey MM, Jameson MJ, Eaton EM, Rosenzweig SA. Insulin-like growth factor binding protein-2: contributions of the C-terminal domain to insulin-like growth factor-1 binding. Molecular Pharmacology 69(3):833-845, 2006.
  • Jameson MJ, Evangelista CA, Rosenzweig SA. Synthesis and characterization of insulin-like growth factor (IGF)-1 photoprobes selective for the IGF binding proteins (IGFBPs): photoaffinity labeling of the IGF-binding domain on IGFBP-2. Journal of Biological Chemistry 276(4):2880-2889, 2001.
  • Jameson MJ, Shirley DS, Kurtz DT, Rosenzweig SA. Elevated glucose increases mesangial cell sensitivity to insulin-like growth factor I. American Journal of Physiology 274(6 Pt 2):F1045-F1053, 1998.
  • Miller BS, Shankavaram UT, Jameson MJ, Gore ACS, Kurtz DT, Rosenzweig SA. Activation of Jun-NH2-terminal kinase/stress-activated protein kinase by insulin. Biochemistry 35(26):8769-8775, 1996.
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