Marie-Louise  Hammarskjold
Degree(s): MD/PhD
Graduate School: Karolinska, Sweden
Primary Appointment: Professor, Microbiology, Immunology, and Cancer Biology
Research Interests:
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Website: http://www.healthsystem.virginia.edu/internet/thaler/home.cfm
Email Address: mh7g@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Biomedical Sciences Graduate Programs
    • Research Description

    Many mammalian and viral genes are alternatively spliced and subject to regulation at the post- transcriptional level. However, relatively little is known about the cellular mechanisms for this regulation. We are using retroviruses as model systems to elucidate these mechanisms. Some of our studies focus on HIV Rev, an essential HIV protein. Rev mediates the nucleo-cytoplasmic export of unspliced and incompletely spliced HIV RNAs and provides an important HIV drug target. Another major focus of the laboratory is the function of the constitutive transport element (CTE). The CTE interacts directly with host cell proteins to facilitate export of intron containing RNA. We are currently analyzing the function of cellular proteins that are involved in the CTE mediated export pathway. One is NXF1 (TAP), a protein which has been proposed to play an essential role in cellular mRNA export. A second protein under study is NXT1, an important TAP cofactor. CTE function is also enhanced by SAM68, a major target of Src and Src family kinases and a potential tumor suppressor. Our studies are aimed at identifying the mechanism by which SAM68 promotes CTE function and the role that this protein plays in cellular gene regulation.

    Selected Publications
  • Swartz JE, Bor YC, Misawa Y, Rekosh D, Hammarskjöld ML. (2007) The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a CTE. J Biol Chem. J Biol Chem. 282 19844-19853.
  • Olivieri, K.C. BS, Scoggins, R. M., Bor, Y-C, Matthews, A., Mark, B.S. ,Taylor, J., Chenauskas, D., Hammarskjöld, M. , Rekosh D. and Hammarskjold, M.L. (2007) The Envelope Gene is a Cytopathic Determinant of CCR5 Tropic HIV-1, Virology 358 23-38.
  • Bor YC, Swartz J, Morrison A, Rekosh D, Ladomery M, Hammarskjöld ML. (2006) The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation from an unspliced RNA with a retained intron. Genes Dev. 20 1597-1608.
  • Li, Y. Bor, Y.-C.,Misawa, Y, Xue, Y, Rekosh , D.,and M.-L. Hammarskjöld (2006) The Tap/NXF1 Gene Contains a Functional CTE in an Intron that is Retained in an Alternatively Spliced mRNA, Nature 2006 443 234-237.
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    Contact Information
      Office Address: PO Box 800734 Jordan Hall, 7-84, 
      Office Phone: +1 434-982-1598, +1 434-982-1597
      Fax Phone: +1 434-982-1590
      Home Phone: +1 434-973-6375

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