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Mark  B.  Williams
Degree(s): PhD
Graduate School: University of Virginia
Primary Appointment: Associate Professor, Radiology
Research Interests:
Design, Development and Optimization of Medical Imaging Technologies
Email Address: mbwilliams@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Biomedical Sciences Graduate Programs
    • Research Description

    The general area of research in my lab is the design, development, and optimization of medical imaging technologies. The following projects are underway: 1) Dual modality breast imaging: We are developing an integrated imaging system that combines the sensitivity of digital mammography with the specificity of scintimammography in a single compact, upright unit. The imaging system functions by obtaining mirror-image x-ray transmission and gamma emission images concurrently with the breast in a single configuration. Co-registration then correlates the gamma and x-ray images to within a fraction of a pixel. 2) Molecular imaging system for small animal research: We are developing a tomographic imaging system that permits simultaneous acquisition of high resolution functional (SPECT) and structural (x-ray CT) images from mice and rats. The resulting fused image correlates the radiotracer distribution with the morphological information provided by the x-ray data. A similar 2-dimensional system is being routinely utilized as a component of the Small Animal Multimodality Imaging Center for mouse and rat studies in gene expression imaging, radiation oncology and diagnostic radiology. 3) Evaluation of basic imaging properties of early commercial systems for digital breast imaging. Characteristics being quantified include sensitivity, linearity, spatial resolution, noise properties, and detective quantum efficiency. We are working with a consortium of detector physicists located across North America to develop uniform evaluation methods and to produce a combined data set.

    Selected Publications
  • More MJ, Narayanan D, Goodale PJ, Majewski S, Welch B, Wojcik R, Kieper DA, and Williams MB. X-ray Stereotactic Lesion Localization in Conjunction with Dedicated Scintimammography. IEEE Transactions on Nuclear Science 2003; 50(5):1636-1642.
  • Williams MB, Stolin AV, and Kundu BK. Investigation of Spatial Resolution and Efficiency Using Pinholes with Small Pinhole Angle. IEEE Transactions on Nuclear Science 2003; 50(5):1562-1568.
  • Williams MB, Narayanan D, More MJ, Goodale PJ, Majewski S, Kieper DA. Analysis of Position-Dependent Compton Scatter in Scintimammography with Mild Compression. IEEE Transactions on Nuclear Science 2003; 50(5):1643-1649.
  • Williams MB, More MJ, Narayanan D, Majewski S, Welch B, Wojcik R, and Kieper DA. Phantom Study of Radiotracer Concentration Quantification in Breast Scintigraphy. IEEE Transactions on Nuclear Science 2003; 50(3):433-438.
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    Contact Information
      Office Address: Box 801339 156 Snyder Bldg 480 Ray C Hunt Dr, 
      Office Phone: +1 434-982-4422, +1 434-243-2687
      Fax Phone: +1 434-924-9435
      Web Site: http://faculty.virginia.edu/mbwlabwebsite/

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