Biomedical Sciences Graduate Program(s)
Biomedical Sciences Graduate Programs
INTRODUCTION: B lymphocytes constitute a major cellular component of the immune system, whose function is to produce secreted proteins called antibodies that protect the host against pathogens. A hallmark of this antibody-based protection is the capacity of specialized B cells, plasma cells (PC), to have a prolonged lifespan and is the raison d'être for vaccines to establish long-term immunity. In healthy individuals, the persistence of PCs is an asset for protective humoral immunity but is a significant liability in PC disorders. Thus, understanding the factors that determine PC development and survival takes on considerable importance in terms of both biology and therapeutics. Our laboratory studies two PC disorders: first, is the PC malignancy, multiple myeloma (MM) and second, is the antibody-mediated autoimmune disease, systemic lupus erythematosus.
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for detailed information about his lab and his research.
Khuda SE, Loo WM, Janz S, Van Ness B, Erickson LD, Deregulation of c-Myc Confers distinct survival requirements for memory B cells, plasma cells, and their progenitors. J Immunol. 2008 Dec 1;181(11):7537-49.
Benson MJ, Erickson LD, Gleeson MW, and Noelle RJ. Affinity of antigen encounter and other early B-cell signals determine B-cell fate. Curr. Opin. Immunol. 2007. 19:1-6.
O'Connor BP, Vogel LA, Zhang W, Loo WM, Shnider D, Lind EF, Ratliff M, Noelle RJ, and Erickson LD. Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor. J. Immunol. 2006 177:7723-7732.
Noelle, R.J. and Erickson, L.D. Determinations of B cell fate in immunity and autoimmunity. Current Directions in Autoimmunity. 8:1-24, 2005.
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