Research Description
Targeted Microbubbles Contrast Echocardiography in Acute Coronary Syndromes.
Goal: Special microbubbles (gas core; phospholipid shell) coated with biotinylated ligands with specific selectivity for inflammatory markers P- and E-selection. The goal is to determine if 1) contrast echocardiography can be used to image molecular signals of inflammation during acute coronary syndrome, and 2) if diagnosis of acute coronary syndrome can be improved by targeting the vascular endothelium for signs of inflammatory response.
Role: Principal Investigator.
Primary Prevention of CHD – Role of Noninvasive Imaging.
Goal: To show that in individuals with Intermediate Risk Profile – the use of carotid imaging for noncoronary atherosclerosis and Stress Echocardiography predicts both short and long-term risk for future CHD.
Role: Primary Investigator.
Selected Publications
Akosah KO, McHugh VL, Barnhart SI, Mathiason MA, Schaper AM, Perlock PA. Pilot Results of the Early Detection by Ultrasound of Carotid Artery Intima-Media Thickness Evaluation (EDUCATE) study. Am J Hypertens. 2007 Nov;20(11):1183-8.
Akosah KO, McHugh VL, Barnhart SI, Schaper AM, Mathiason MA, Perlock PA, Haider TA. Carotid ultrasound for risk clarification in young to middle-aged adults undergoing elective coronary angiography. Am J Hypertens. 2006 Dec;19(12):1256-61.
Akosah KO, McHugh VL, Mathiason MA, Kulkarni A, Barnhart SI. Metabolic Syndrome and Coronary Heart Disease Equivalent Conditions in Predicting Cardiovascular Events in Young to Middle-Aged Adults. Journal of the Cardiometabolic Syndrome, 1;3:173-177 (Summer, 2006).
PubMed Link for this Faculty Member
Intranet Profile
(Find Out How to Update Your Faculty Profile)
|
Medical Students 
Graduate Medical Education 
