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Jing  Yu
Degree(s): Ph.D.
Graduate School: Cornell University
Primary Appointment: Assistant Professor, Cell Biology
Research Interests:
Mammalian kidney development

Email Address: jy4m@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Molecular Cell and Developmental Biology
    • Research Description

    Proper formation of epithelial architecture is integral for development and function of most organs. Research interests in the Yu laboratory focus on epithelial morphogenesis during organogenesis, using the mammalian kidney as the model system. The formation and organization of renal epithelia involves multiple mechanisms commonly employed in the formation of epithelial organs, thus provides an excellent model for the study of epithelial morphogenesis. We have recently identified that Wnt7b signaling plays critical roles in the regulation of renal collecting duct epithelium morphogenesis underlying renal cortico-medullary patterning. We will take advantage of a combination of genetic, in vitro organ and cell culture, cell biology and biochemical approaches to dissect the inter- and intra-cellular machineries mediating Wnt7b signaling in renal epithelial morphogenesis. It is our hope that our study will extend the knowledge of molecular circuits orchestrating epithelial morphogenesis and provide tools for prevention, detection and treatment of renal diseases arising from defective epithelial formation or maintenance.

    Selected Publications
  • Yu J. and McMahon A.P (2006). Inducible and reproducible knockdown of gene expression in mice. Genesis. 44, 252-61.
  • Gray P.A., Fu H., Luo P., Zhao Q., Yu J., Ferrari A., Tenzen T., Yuk D., Tsung E.F., Cai Z., Alberta J.A., Chen L., Liu Y., Stenman J.M., Valerius M.T., Billings N., Kim H.A., McMahon A.P., Rowitch D.H., Stiles C.D., and Ma Q (2004). Mouse brain organization revealed through direct genome scale transcription factor expression analysis. Science 306(5705), 2255-7.
  • Yu J., McMahon A.P., Valerius M. (2004) Recent genetic studies of mouse kidney development. Curr. Opin. Genet. Dev.14(5), 550-7.
  • Yu, J., Carroll, T.J., and McMahon, A.P. (2002) Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129, 5301-5312.
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    Contact Information
      Office Address: PO Box 800732, 
      Office Phone: +1 434-982-0203

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