Jeffrey  W.  Holmes
Degree(s): MD/PhD
Graduate School: UC San Diego
Primary Appointment: Associate Professor, Biomedical Engineering
Research Interests:
Healing after myocardial infarction, cardiac growth and remodeling, and image-based modeling and diagnosis.
Website: http://bme.virginia.edu/people/holmes.php
Email Address: holmes@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Biomedical Sciences Graduate Programs
    • Research Description

    The Cardiac Biomechanics Group focuses on the interactions between mechanics, function, and growth and remodeling in the heart. The mechanical properties of normal and diseased myocardium are important determinants of overall heart function. These mechanical properties change during growth, remodeling or disease, often in part as a response to changes in the mechanical environment. Our group studies this interplay between mechanical environment, tissue response, and heart function, not only to better understand the basis for heart disease but also to identify new opportunities to intervene. Current Projects: Currently, most of our projects are related to myocardial infarction (MI): 1. a translational effort to help prevent MI by developing new quantitative measures of heart wall motion that improve screening for coronary artery disease; 2. a basic biomechanics project focused on understanding how the structure of a healing infarct gives rise to its mechanical properties and how those mechanical properties influence overall heart function; and 3. longer-term efforts to determine how mechanical factors regulate both cardiac wound healing and remodeling of non-infarcted myocardium in post-MI patients

    Selected Publications
  • Fomovsky GM, Thomopoulos S, Holmes JW Contribution of extracellular matrix to the mechanical properties of the heart. J Mol Cell Cardiol. 2009 Aug 15.
  • Duan Q, Angelini ED, Herz SL, Ingrassia CM, Costa KD, Holmes JW, Homma S, Laine. AF Region-based endocardium tracking on real-time three-dimensional ultrasound. Ultrasound Med Biol. 2009 Feb;35(2):256-65. Epub 2008 Oct 29.
  • Lee WN, Ingrassia CM, Fung-Kee-Fung SD, Costa KD, Holmes JW, Konofagou EE. Theoretical quality assessment of myocardial elastography with in vivo validation. EE Trans Ultrason Ferroelectr Freq Control. 2007 Nov;54(11):2233-45.
  • Holmes JW, Costa KD . Imaging cardiac mechanics: what information do we need to extract from cardiac images?. Conf Proc IEEE Eng Med Biol Soc. 2006;1:1545-7.
  • PubMed Listings for this Faculty Member
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    Contact Information
      Office Address: PO BOX 800759 415 Lane Road, Room 2014, 
      Office Phone: +1 434-243-6321
      Fax Phone: +1 434-982-3870

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