BIMS Affiliated Research Faculty

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Dennis  J.  Templeton
Degree(s): MD/PhD
Graduate School: University of California, San Diego
Primary Appointment: Professor, Pathology
Research Interests:
Cell Death in Cancer Progression; Stress-Mediated Signal Transduction; Cancer Chemoprevention; Stress Inhibitors in Inflammatory Diseases
Email Address: templeton@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Biomedical Sciences Graduate Programs
    • Research Description

  • Protein kinase cascades that control cell signaling and cell cycle transition
  • Mechanism of action of inflammatory cytokines in human disease processes
  • Mechanism of cancer chemoprevention agents that control signal transduction and cell death
  • Proteomic strategies to identify cancer control gene products using novel affinity labels and mass spectrometry

    • Selected Publications
  • Cross, JV, and Templeton, DJ (2006) Regulation of Signal Transduction Pathways by Protein Oxidation. Antiox Redox Signaling (in Press).
  • Zhang C, Kenski DM, Paulson JL, Bonshtien A, Sessa G, et al. (2005) A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases. Nat Methods 2: 435-441.
  • Cross, J.V. and D. J. Templeton, Thiol Oxidation of Cell Signaling Proteins: Controlling an Apoptotic Equilibrium. J. Cell Biochem, 2004 Sep 1;93(1):104-11.
  • Cross, J.V. and D.J. Templeton, Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP binding domain. Biochem J, 2004. Aug.1;381(Pt 3):675-83.
  • PubMed Listings for this Faculty Member
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    Contact Information
      Office Address: PO Box 800904 MR 5 Room 3073A, 
      Office Phone: +1 434-924-1946
      Fax Phone: +1 434-924-9312

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