Diane  L.  Rosin
Degree(s): PhD
Graduate School: Virginia Commonwealth University
Primary Appointment: Assistant Professor, Pharmacology
Research Interests:
Central catecholamine dysfunction
Email Address: dr5e@virginia.edu
Research Description

I am interested in understanding immune mechanisms involved in acute and chronic kidney injury and the mechanisms that may underlie the progression of acute to chronic kidney disease.  The availability of a large array of transgenic mice contributes important tools for teasing out these mechanisms.  We use a variety of in vivo and in vitro models along with molecular, cell biological and immunological methods to study kidney injury and to guide development of novel pharmacological and cell based therapy approaches for modulating pathways that contribute to kidney injury.  Some of our current work focuses on using ligands of adenosine 2A receptors and sphingosine 1 receptors to protect kidneys from insults that produce acute and chronic kidney injury.  In addition we are exploring nanoparticle-mediated targeted delivery of drugs to kidney as a novel and possibly more selective treatment modality. 

Some of the models that we use include:

1) Kidney ischemia-reperfusion injury as a model of acute kidney injury

2) Folic acid or aristolochic acid-induced kidney fibrosis.  Interstitial fibrosis is one of the hallmarks of chronic kidney disease

3) Ischemia-reperfusion injury-induced fibrosis in mice maintained for longer time periods as a model of progression from acute to chronic kidney injury.

4) Hypoxia- or LPS-induced injury in cultured renal tubular epithelial cells, glomerular endothelial cells, and primary cultures of kidney fibroblasts.

Selected Publications
  • Rosin DL and Okusa, MD. Dangers within: damp responses to danger and cell death in kidney disease. J Amer Soc Nephrol, 22:416-425, 2011. PMID: 21335516.
  • Bajwa A, Jo SK, Ye H, Huang L, Dondeti, K, Rosin DL, Haase VH, Mcdonald TL, Lynch KR and Okusa MD. Activation of sphingosine 1-phosphate receptor in the proximal tubule protects against ischemia-reperfusion injury. J Amer Soc Nephrol, 21:966-965, 2010. PMCID: PMC2900956.
  • Li L, Huang L, Vergis AL, Ye H, Bajwa A, Narayan V, Strieter RM, Rosin DL and Okusa MD. IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. J Clin Invest 120:331-342, 2010. PMCID: PMC2798679.
  • Li Li, Huang L, Sung SS, Vergis AL, Rosin DL, Rose CE Jr, Lobo PI, Okusa MD. The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury. Kidney Int. 74:1526-37, 2008. PMCID: PMC2652647.
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    Contact Information
      Office Address: PO Box 800746 Jordan Hall, rm 4043B Div. of Nephrology, 
      Office Phone: +1 434-243-6699
      Fax Phone: +1 434-924-5848
      Home Phone: +1 434-979-4392

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