Biomedical Sciences Graduate Program(s)
Biomedical Sciences Graduate Programs
My lab focuses on intercellular communication in the microvasculature and how this regulates the critical proces of vessel dilation and constriction--elucidating this fundamental proces is key to understanding such diseases as hypertention and the associated vascular dysfunction seen with obesity.
To that end, our lab is keenly interested in the membrane bound proteins connexins (which link cellular cytoplasm together physically) and pannexins (which signal other cells by releasing ATP into the extracellular environment), as well as how nitric oxide may regulate these channels directly, or act independantly based on it's cellular localization in the vessel wall.
Our lab utilizes everything from gene knockout animals and isolated intact blood vessels, to unique cell culture techniques and molecular biology, to biphysical techniques such as analytical size exclusion. We believe this is the best way to tackle the most pressing and interesting biological questions.
Lastly, we strive to place creativity over dogma.
Isakson B.E. Localized expression of Ins (1,4,5) P3 receptor at the myoendothelial junction selectivly regulates heterocellular Ca2+ communication. J. Cell Sci, 121:3664-3673, 2008.
Isakson, B. E., S. I. Ramos, and B. R. Duling. Ca2+ and inositol 1,4,5-trisphosphate mediated signaling across the myoendothelial junction Circ Res, 100: 670-80, 2007.
Isakson, B. E., G. Kronke, A. Kandl, N. Leitinger, and B. R. Duling. Oxidized phospholipids alter vascular connexin expression, phosphorylation and heterocellular communication. Athero Thromb Vasc Biol 26: 2216-21, 2006.
Isakson, B. E. and B. R. Duling. Heterocellular contact at the myoendothelial junction influences gap junction organization. Circ Res 97: 44-51, 2005.
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