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Anindya  Dutta
Degree(s): MD/PhD
Graduate School: University of Madras; Rockefeller University
Primary Appointment: Harry F. Byrd Professor and Chair, Biochemistry and Molecular Genetics
Research Interests:
DNA Replication and Genomic Instability in Cancer Cells
Website: http://genome.bioch.virginia.edu
Email Address: ad8q@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Biomedical Sciences Graduate Programs
    • Research Description

    Our lab studies the genetics and genomics of the cell-cycle in normal and cancer cells with an emphasis on microRNAs, DNA replication and DNA damage. The projects in the lab are summarized below: (1) We have focused on microRNAs that regulate cell-cycle progression during muscle differentiation or in prostate cancers, with a special emphasis on potential tumor suppressor microRNAs. We discover microRNAs that change under specific conditions using techniques like microarrays and cloning/high-throughput sequencing and identify the targets of the relevant microRNAs. (2) A better knowledge of how DNA replication is initiated or regulated in mammalian cells will allow us to devise (or discover) inhibitors that restrain DNA replication in cancer cells and understand how disorders in their regulation lead to genomic instability. For example, we map origins of replication in human cells using genome tiling arrays or high throughput sequencing and study how use of the origins is altered by chemotherapy drugs. We also study the how replication initiation-factors and cell-cycle regulators are regulated by ubiquitylation both in the normal cell-cycle and in response to DNA damage. (3) We study how the Tip60 acetyltransferase and tumor suppressor is involved in the normal response of a cell to DNA damage and how tumor producing viruses like Human Papilloma Virus subvert this response pathway. Similarly, we study how experimental anti-cancer drugs like MLN4924 de-regulate the cell-cycle to cause re-replication and DNA damage.

    Selected Publications
  • Dey BK, Gagan J and Dutta A. MiR-206 and -486 induce myoblast differentiation by downregulating Pax7. Mol. Cell Biol., 2011, 31:203-14. PMC3019853.
  • Abbas T, Shibata E, Park J, Jha S, Karnani N and Dutta A. CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation. Molecular Cell, 2010, 40: 9-21. PMC2966975.
  • Jha S, Vande Pol S, Banerjee NS, Dutta AB, Chow LT, and Dutta A. Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60 dependent transcriptional regulation and apoptotic pathway. Molecular Cell, 2010, 38:700-11 PMC2886028.
  • Lee YS, Shibata Y, Malhotra A and Dutta A. A novel class of small RNAs: tRNA-derived RNA fragments (tRFs). Genes & Development, 2009; 23:2639-49. PMC2779758.
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    Contact Information
      Office Address: PO Box 800733, 
      Office Phone: +1 434-924-1227
      Web Site: http://genome.bioch.virginia.edu/

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