Contact:Katie Sullivan
Phone:(434)243-7231
E-mail:kls8d@virginia.edu
UVa Health System, Department of Radiation Oncology seeks Women and Men, 18 years of age and older, with newly diagnosed rectal cancer for research study.
Several normal tissues in your pelvis (including the small and large bowel, bladder, and others) lie near the rectal tumor and nearby lymph nodes. Standard radiation techniques deliver radiation to the tumor target but in doing so also deliver some radiation dose to the nearby normal tissues. The higher the radiation dose to these normal tissues, the greater the risk of developing side effects. IMRT is a more advanced radiation planning and delivery technique that can lower the amount of radiation dose that the normal tissues receive while maintaining effective treatment to the tumor target.
The standard treatment for stage III-IV of rectal cancer is radiation therapy with or without chemotherapy followed by surgery with subsequent chemotherapy. The experimental part of the chemotherapy used in this trial is the addition of oxaliplatin to the concurrent chemoradiation treatment program. Oxaliplatin is FDA approved for stage III colorectal carcinoma and for metastatic colorectal cancer but not yet approved for patients with rectal cancer.
The purpose of the study is to determine whether reducing the amount of radiation given along with chemotherapy (including Oxaliplatin) to normal tissues will reduce the side effects associated with standard radiation and chemotherapy treatment for rectal cancer.
Study treatment will last 8 to 9 months. The study involves taking an experimental medicine, blood draws, CT scans, x-rays and overnight stays.
Participant's insurance company will be billed for medication, tests and procedures.
No compensation is provided for this study.
Contact Information:
For more information please contact:
" Katie L. Sullivan, MSW, CCRC
" 434-243-7231, kls8d@virginia.edu
" Insert IRB-HSR # 13851
Principal Investigator: Tyvin Rich, MD
434-924-5191
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Primary Investigator: Rich Tyvin, A