University of Virginia Health System

EDUCATION:

SUNY at Stony Brook; MD (1990), Ph.D (Aug 1990)
University of California, San Francisco, Anatomic/Neuropathology Residency/Fellowship, 1990 - 1994
University of California, San Francisco, Pathology Research Fellow 1993 - 1994
University of California, San Francisco, Post-doctoral Fellow/Semi-Independent Scientist 1994 - 2000

CLINICAL:

Special Interest: Neuropathology

Responsibilities: Attending, Autopsy Service

RESEARCH:

Nuclear receptors regulate a wide range of physiologic and pathophysiologic processes including maintenance of bone density and regulation of growth. They belong to a large superfamily that includes the steroid receptors (e.g. estrogen and glucocorticoid receptors) and receptors for small lipophilic molecules (e.g. vitamin D and thyroid hormone). We are studying the mechanisms by which two nuclear receptors, the estrogen and glucocorticoid receptors regulate transcription through novel pathways. Using molecular studies we have found a highly informative mutation that facilitates analysis of estrogen receptor-mediated transcriptional regulation. When used to generate transgenic mice, this mutation reveals a potent growth regulatory region of the estrogen receptor. We are pursuing analysis of this region by combining in vitro and in vivo approaches.

See http://hsc.virginia.edu/bmg/faculty/Uht/Uht.htm for a more detailed description of research interests.

REFERENCES:

• Price RH Jr, Butler CA, Webb P, Uht RM, Kushner P, Handa RJ> A splice variant of estrogen receptor beta missing exon 3 displays altered subnuclear localization and capacity for transcriptional activation. Endocrinology. 2001 May;142(5):2039-2049.
• Kushner PJ, Agard DA, Greene GL, Scanlan TS, Shiau AK, Uht RM, Webb P. Estrogen receptor pathways to AP-1. J Steroid Biochem Mol Biol. 2000 Nov 30;74(5):311-317.
• Kushner PJ, Agard D, Feng WJ, Lopex G, Schiau A, Uht RM, Webb P, Greene G. Oestrogen receptor function at classical and alternative response elements. Novartis Found Symp. 2000:230:20-26; discussion 27-40.
• Rowley HA, Uht RM, Kazacos KR, Sakanari J, Wheaton WV, Barkovich AJ, Bollen AW. Radiologic-pathologic findings in raccoon roundworm (Baylisascaris procyonis) encephalitis. AM J Neuroradiol. 2000 Feb;21(2):415-420.
• Anderegg, B.*, R. M. Uht,*, A.C. Rossi, K.E. Hilty, P. Webb, C.M.Anderson, D.B. Starr, P. J. Kushner, and Jeffrey M. Arbeit (2000) Mutant estrogen receptor (ER-a.K206A) transgenic mice develop lower reproductive tract enlargement and squamous hyperplasia with neoplastic features. *The two first authors contributed equally to the manuscript, they are listed alphabetically. (In preparation)
• Uht, R.M., K. Hilty, and P.J. Kushner. (2000) ER and GR transcriptional regulation is integrated through steroid receptor co-activators. (In preparation).
• Ding X.F., C.M Anderson, H. Ma, H. Hong, R.M. Uht, P.J. Kushner, and M.R. Stallcup (1998). Nuclear receptor-binding sites of coactivators glucocorticoid receptor interacting protein 1 (GRIP1) and steroid receptor coactivator 1 (SRC-1): multiple motifs with different binding specificities. Mol. Endo., 1998 Feb, 12(2):302-13.
• Uht, R.M., C.M. Anderson, P. Webb, and P.J. Kushner (1997). Transcriptional Activities of Estrogen and Glucocorticoid Receptors Are Functionally Integrated at the AP-1 Response Element. Endocrinology. 138(7):2900-8.
• Webb, P., G.N. Lopez, R.M. Uht, and P.J. Kushner (1995). Tamoxifen activation of the Estrogen Receptor/AP-1 pathway: Potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol. Endo. 9:443-456.