Henry Frierson

Henry F. Frierson, Jr., M.D.

Professor of Pathology


EDUCATION:
College: Davidson College , 1977, BS
Medical School: Medical University of South Carolina , 1981, MD
Residency: University of Virginia (AP/CP), 1981-1985

CLINICAL:
General surgical pathology and cytopathology

RESEARCH:
Role of genes and gene products in prostate and salivary cancers; clinical and molecular aspects of adenoid cystic carcinoma; transgenic mouse models of prostate and salivary carcinomas.

REFERENCES:

  • Yu Y, Baras AS, Shirasuna K, Frierson HF Jr, Moskaluk CA: Concurrent loss of heterozygosity and copy number analysis in adenoid cystic carcinoma by SNP genotyping arrays. Lab Invest. 2007;87: 430-439. 
  • Deeble PD, Cox ME, Frierson HF Jr, Sikes RA, Palmer JB, Davidson RJ, Casarez EV, Amorino GP, Parsons SJ: Androgen-independent growth and tumorigenesis of prostate cancer cells are enhanced by the presence of PKA-differentiated neuroendocrine cells. Cancer Res. 2007;67: 3663-3672. 
  • Meinhold-Heerlein I, Bauerschlag D, Zhou Y, Sapinoso LM, Ching K, Frierson HF Jr, Brautigan K, Sehouli J, Stickeler E, Konsgen D, Hilpert F, von Kaisenberg CS, Pfisterer J, Bauknecht T, Jonat W, Arnold N, Hampton GM: An integrated clinical-genomics approach identifies a candidate multi-analyte blood test for serous ovarian carcinoma. Clin Cancer Res. 2007;13: 458-466. 
  • Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF: Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis. Lancet Oncol.  2006;7: 230-240. 
  • Hong SM, Presley AE, Stelow EB, Frierson HF Jr, Moskaluk CA: Reconsideration of the histologic definitions used in the pathologic staging of extrahepatic bile duct carcinoma. Am J Surg Pathol. 2006;30: 744-749. 
  • Smith SC, Oxford G, Wu Z, Nitz MD, Conaway M, Frierson HF, Hampton G, Theodoresu D: The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer. Cancer Res. 2006;66: 1917-1922. 
  • Galgano MT, Hampton GM, Frierson HF Jr: Comprehensive analysis of HE4 expression in normal and malignant human tissues. Mod Pathol. 2006;19: 847-853. 
  • Wu Z, Sidaty MS Riddick G, Frierson HF, Lee JK, Golden W, Knuutila S, Hampton GM, El-Rifai W, Theodorescu D: A novel method for gene expression mapping of metastatic competence in human bladder cancer. Neoplasia 2006;8: 181-189. 
  • Hong SM, Cho H, Moskaluk CA, Frierson HF Jr, Yu E, Ro JY. CDX2 and MUC2 protein expression in extrahepatic bile duct carcinoma. Am J Clin Pathol. 2005 Sep;124(3):361-70.
  • Rutherford S, Hampton GM, Frierson HF Jr, Moskaluk CA.  Mapping of candidate tumor suppressor genes on chromosome 12 in adenoid cystic carcinoma. Lab Invest. 2005 Sep;85(9):1076-85.
  • Titus B, Frierson HF Jr, Conaway M, Ching K, Guise T, Chirgwin J, Hampton G, Theodorescu D.  Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. Cancer Res. 2005 Aug 15;65(16):7320-7.
  • Johnson AH, Frierson HF, Zaika A, Powell SM, Roche J, Crowe S, Moskaluk CA, El-Rifai W. Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis. Am J Pathol. 2005 Aug;167(2):577-84.
  • Rutherford S, Yu Y, Rumpel CA, Frierson HF Jr, Moskaluk CA.  Chromosome 6 deletion and candidate tumor suppressor genes in adenoid cystic carcinoma. Cancer Lett. 2005 Jul 27.
  • Goodman MT , Hernandez BY,Hewitt S, Lynch CF, Cote TR, Frierson HF Jr, Moskaluk CA ,Killeen JL, Cozen W, Key CR, Clegg L, Reichman M, Hankey BF, Edwards B. Tissues from population-based cancer registries: a novel approach to increasing research potential. Hum Pathol. 2005 Jul;36(7):812-20.
  • Ozyildirim AM, Wistow GJ, Gao J, Wang J, Dickinson DP, Frierson HF Jr, Laurie GW.  The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts.  Invest Ophthalmol Vis Sci. 2005 May;46(5):1572-80.
  • Clark DE , Errington TM, Smith JA, Frierson HF Jr, Weber MJ, Lannigan DA.  The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation. Cancer Res. 2005 Apr 15;65(8):3108-16.
  • Sun X, Frierson HF Jr, Chen C, Li C, Ran Q, Otto KB, Cantarel BL, Vessella RL, Gao AC, Petros J, Miura Y, Simons JW, Dong JT. Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer. Nat Genet. 2005 Apr;37(4):407-12.
  • Fox CA, Sapinoso LM, Zhang H, Zhang W, McLeod HL, Petroni GR, Mullick T, Moskaluk CA, Frierson HF Jr, Hampton GM, Powell SM.  Altered expression of TFF-1 and CES-2 in Barrett's Esophagus and associated adenocarcinomas. Neoplasia. 2005 Apr;7(4):407-16.

 

A current list of Dr. Frierson's journal publications can be obtained from PubMed.