David E. Bruns, M.D.

Professor of Pathology
Director of Clinical Chemistry and Toxicology
Associate Director of Molecular Diagnostics Laboratory

David Bruns 2008

 

EDUCATION -

Medical School: St. Louis University, MD, 1973
Residency and Fellowship: Departments of Pathology and Internal Medicine, Washington University, 1973-1977

CLINICAL -

Clinical chemistry and molecular diagnostics.

RESEARCH -   

  • Evidence-based laboratory medicine
  • Assessment of diagnostic accuracy of clinical tests

EDITORSHIP -

  • Editor, Clinical Chemistry, 1990 – 2007; Perspectives Editor, 2008 - present: Clinical Chemistry (Online Edition)

ELECTED OFFICE -

  • President, Association of Clinical Scientists, 1986
  • President, Academy of Clinical Laboratory Physicians and Scientists, 2005-2006

 
RECENT REFERENCES –

  • Bruns DE. Improving training in laboratory medicine. Clin Chim Acta (In press)
  • Rifai N, Bossuyt PMM, Bruns DE. Identifying Duplicate Publications: Primum non Nocere. Clin Chem. 2008 Feb 19; [Epub ahead of print]
  • Mikesh LM, Crowe SE, Bullock GC, Taylor NE, Bruns DE. Celiac disease refractory to a gluten-free diet? Clin Chem. 2008 Feb;54(2):441-4.
  • Henrich LM, Bruns DE, Haverstick DM, Reynolds V, Boyd JC. Indican interference in bilirubin assays: a classical solution still applies. Clin Chem 2007;53:359-361.
  • Henrich LM, Rogol AD, D'Amour P, Levine MA, Hanks JB, Bruns DE. Persistent hypercalcemia after parathyroidectomy in an adolescent and effect of treatment with cinacalcet HCl. Clin Chem 2006;52:2286-93.
  • Scott M, Bruns DE. Improving training in laboratory medicine. Clin Chem 2006;52:915-6.
  • Haverstick DM, Bullock GM, Bruns DE. Genotyping of hepatitis C virus (HCV) by melting curve analysis: Analytical characteristics and performance. Clin Chem 2004;50:2405-7.  
  • Oosterhuis WP, Bruns DE, Watine J, Sandberg S, Horvath AR. Recommendations for evidence-based guidelines in laboratory medicine. Clin Chem 2004;50:806-18.  
  • Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis C, Glasziou P, Irwig L, Moher D, et al. Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative. Explanation and elaboration. Ann Intern Med 2003;138:W1-W12. Clin Chem 2003;49:7-18.  
  • Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis C, Glasziou P, Irwig L, Lijmer JG, et al. The STARD Initiative: Towards Complete and Accurate Reporting of Studies of Diagnostic Accuracy. Acad Radiol 2003;10:664-9. AJR Am J Roengenol 2003;181:51-5. Ann Clin Biochem 2003;40(pt 4):357-63. Ann Intern Med 2003;138:40-44. Am J Clin Pathol 2003;119:18-22. BMJ 2003;326:41-44. Clin Biochem 2003;36:1-7. Clin Chem 2003;49:1-6. Clin Chem Lab Med 2003;41:68-73. Ned Tijdschr Geneeskd 2003;147:336-40 (Dutch). Radiology 2003;226:24-8.  
  • Sacks DB, Bruns DE, Goldstein DE, Maclaren NK, McDonald JM, Parrott M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem 2002;48:436-72 and Diabetes Care 2002;25:750-86.
  • Parrish D, Bruns DE. US legal principles and confidentiality of the peer review process, JAMA 2002;5;287:2839-41   
  • Bullock, GC, Bruns DE, Haverstick DM. Hepatitis C genotype determination by melting cuve analysis with a single set of fluorescence resonance energy transfer probes. Clin Chem 2002; 48:2147-54

 
RECENT BOOKS -

  • Burtis CA, Ashwood EA, Bruns DE, eds. Tietz Fundamentals of Clinical Chemistry. 6th ed. St. Louis: Saunders/Elsevier, 2008.   
  • Bruns DE, Ashwood ER, Burtis CA, eds. Fundamentals of Molecular Diagnostics. St. Louis: Saunders/Elsevier, 2007.
  • Burtis CA, Ashwood ER, Bruns DE, eds., Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 4th ed., St. Louis: Saunders/Elsevier, 2006.
  • Bruns DE, Lo YMD, Wittwer CT, eds. Molecular Testing in Laboratory Medicine.  Washington: AACC Press, 2002.

RECENT BOOK CHAPTERS -

  • Price CP, Bossuyt PMM, Bruns DE, Introduction to Clinical Chemistry and Evidence-Based Laboratory Medicine. Chapter 1 In Burtis CA, Ashwood ER, Bruns DE, eds. Fundamentals of Clinical Chemistry. St.Louis: Suanders/Elsevier, 2008.   
  • Bruns DE, Price CP, Bossuyt PMM. Introduction to Evidence-Based Molecular Diagnostics. In Bruns DE, Ashwood ER, Burtis C, eds. Fundamentals of Molecular Diagnostics. St. Louis: Saunders/Elsevier, 2007.
  • Chute D, Bruns DE.  Metabloic Acidosis of Unknown Origin Among Burn Patients.  In Scott MG, Gronowski AM, Eby CS. Tietz Applied Laboratory Medicine. Philadelphia: Lippincott Williams & Wilkins. 2007.
  • Presley AE, Bruns DE. A Happy but Developmentally Delayed 5-Year-Old Boy.  Ibid 2007.
  • Henrich LM, Rogol AD, Bruns DE. A 10-Year Old Boy with Pain-Induced Seizures.  Ibid 2007.
  • Bruns DE, Bennett.  A 9-Year-Old Boy with Skin Lesions and Headaches. ibid. 2007.    

 
RECENT INVITED LECTURES

  • Use of Methodological Standards in Studies of Diagnostic Accuracy: Getting Better but Still Not Good 10 Years after Reid, Lachs and Feinstein.  Academy of Clinical Laboratory Physicians and Scientists.  Denver, June 4, 2004.   
  • Laboratory-related Outcomes in Healthcare.  Tenth Asian-Pacific Congress of Clinical Biochemistry. Perth, Australia.  September 22, 2004.
  • Summarise the Evidence.  Workshop on Evidence-based Medicine. Freematle, Western Australia.  September 24, 2004.
  • Methodological Standards in Studies of Diagnostic Accuracy: Getting Better, But Still Not Good.  Greek Society of Clinical Chemistry.  Athens, November 18, 2004.
  • Effects of analytical imprecision and bias on patient care.  Mayo Foundation Symposium.  Orlando, Florida.  July 23, 2005.
  • Interferences Matter.  Australasian Association of Clinical Biochemists.  Sydney, Australia. October 6, 2005.
  • The STARD Initiative.  Department of Pathology, Brigham and Womens Hospital and Harvard University.  April 20, 2006.
  • Excellence in Patient-Centered Laboratory Medicine: Challenges for Academia, Industry and Government. University of Cape Town. South Africa. June 26, 2006.
  • Views of Clinical Chemistry from the Journal Clinical Chemistry. Universities of Stellenbosch and Pretoria, South Africa. June 29, 2006.
  • Excellence in Patient-Centered Laboratory Medicine: Challenges for Academia, Industry and Government. Medical University of South Africa. June 30, 2006.
  • Views of Clinical Chemistry from the Journal Clinical Chemistry. South African Association of Clinical Biochemists. Durban, South Africa. July 3, 2006.
  • Excellence in Patient-Centered Laboratory Medicine: Challenges for Academia, Industry and Government. 46th Conference of the Federation of South African Societies of Pathology.  Durban, South Africa.  July 4, 2006.
  • Do We Need Journals Anymore? Athena Society Triennial Meeting. Mykonos, Greece.  September 6, 2006.
  • Assessment of the Accuracy of Diagnostic Tests. Symposium on Scientific Principles and Clinical Practice in Assessment of Diagnostic Tests.  Seoul, South Korea, September 4, 2007.
  • Do We Know the Diagnostic Accuracy of the Tests We Perform? Macgregor Lecture, Department of Pathology, University of Alberta, Edmonton, Alberta, Canada, October 4, 2007.
  • Improving Training in Laboratory Medicine.  Keynote Lecture. International Conference on Laboratory Medicine. Padua, Italy, October 23, 2007.
  • How Accurate are Glucose Meters - How Accurate Do They Need to Be - Are New Meters Substantially Better?  American Diabetes Association.  San Francisco, June 8, 2008.
  • Laboratory measurement of urine albumin. American Association for Clinical Chemistry Annual Meeting, Washington, DC, July 31, 2008.
  • Diabetes and prediabetes: Laboratory update and new diagnostic perspectives. IFCC International Congress, Fortaleza, Brazil, October 1, 2008.


    A current list of Dr. Bruns' journal publications can be obtained from PubMed