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Title: Professor of Pathology, Professor of Microbiology
Contact: Kenneth Tung, M.D. kst7k@Virginia.EDU
Laboratory interests:
Factors responsible for immunological self tolerance and autoimmune disease development. Focus is on 1) regulatory T cell response to endogenous self antigens, and 2) mechanism of autoimmune inflammation.
Research projects:
1. Ontogeny and accessibility of self Ag in tolerance induction.
2. Mechanism of immune privilege.
3. Antigen specific natural regulatory T cells as mechanism of tolerance.
4. Epitope spreading in autoimmune disease.
What you will learn from this rotation:
1. Adult and neonatal experimental autoimmune diseases.
2. Mouse immunogenetics
3. Autoantibody detection.
4. Antigen specific T cell detection and functional analysis.
5. Isolation of leukocyte subsets.
6. Flow cytometric analysis of leukocytes.
7. Immunohistology.
8. Mouse surgery.
9. Transgenic models of autoimmunity.
Principles:
- Imbalance of regulatory and effector T cell function determines autoimmune disease pathogenesis.
- Endogenous antigens are critical in regulating tolerance and autoimmunity.
- Propensity of neonatal mice to autoimmune response and disease.
- Early immunological events prime individuals for late onset autoimmunity.
- Factors that obscure the detection of target autoantigen and disease mechanism.
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