Research Opportunities -

Goldfarb Lab

http://www.med.virginia.edu:80/medicine/clinical/pathology/Faculty/goldfarb.jpg

goldfarb1

 

 

 

 

 

Title: Associate Professor of Pathology, Associate Director of Clinical Hematology Laboratory
Contact: Adam N.Goldfarb, M.D. (ang3x@virginia.edu)

Laboratory Interests: Molecular signals that control development of blood cells in the human bone marrow

Research Projects:
1.  The role of the AP-1 transcription factor family in normal and diseased development of red cells and megakaryocytes

2.  Novel regulatory interaction discovered between the RUNX and GATA families of transcription factors in megakaryocyte development

3.  Dissection of the role of a novel signaling pathway discovered connecting the Notch signaling pathway with GATA transcription factors

4.  Dissecting the molecular mechanisms of an extremely common disease: iron deficiency anemia

What you will learn on this rotation:
1.  An understanding of how bone marrow stem cells make lineage commitment decisions

2.  Understand how normal development occurs in erythroid (red cell producing) and megakaryocytic (platelet producing) lineages

3.  Understand how the normal developmental mechanisms are subverted in both leukemia and in benign anemias