Kevin C. Hazen, Ph.D.

Professor of Pathology
Director of Clinical Microbiology Laboratory

EDUCATION:

Graduate School: Montana State University, Ph.D, 1982
Post Doctoral: Washington University, NIH Post-Doctoral fellow, Infectious Diseases, 1982 - 1984

CLINICAL:

Mycology, mycobacteriology, and antifungal susceptibility testing methods and rapid identification methods.

RESEARCH:

Fungal pathogenesis. Fungal surface proteins and hydrophobicity. My laboratory is concerned with the biochemistry and molecular biology of surface hydrophobic protein expression of medically important fungi, especially Candida. We are also interested in characterizing the role and regulation of surface protein glycosylation as it affects surface hydrophobins (hydrophobic adhesins) interactions with host and prosthetic surfaces. The role of surface hydrophobic proteins in tissue specific adhesion by Candida sp. is also under investigation. Biochemical, molecular genetics, biophysical and histological methods are used in our studies.

REFERENCES:

  • Hazen KC, SA Howell. 2007. Candida, Cryptococcus and other yeasts of medical importance. pp. 1762-1788. In: Manual of Clinical Microbiology, 9th Edition. ASM Press, Washington DC.
  • Masuoka J, KC Hazen . 2006. Effect of monosaccharide composition, and glycosidic linkage position and anomericity on electrophoretic mobility of labeled oligosaccharides. Electrophoresis 27: 365-372.
  • Singleton DR, J Masuoka, KC Hazen . 2005. Surface hydrophobicity changes of two C. albicans serotype B mnn4 Δ mutants. Eukaryotic Cell. 4: 639-648.
  • Wetter TJ, KC Hazen , JE Cutler. 2005. Comparison between Aspergillus fumigatus conidia and hyphae susceptibilities to amphotericin B, itraconazole, and voriconazole using the mold rapid susceptibility assay. Med. Mycol. 43: 525-532. 
  • Hazen KC, J Stie, C Darracott, Aodhan Breathnach, Joanna May, SA Howell. 2005. Isolation of bile-dependent Candida glabrata from clinical specimens. Diag. Microbiol. Infect. Dis. 52(1): 35-37.
  • Singleton DR, PL Fidel Jr., KL Wozniak, KC Hazen . 2005. Contribution of cell surface hydrophobicity protein 1 (Csh1p) to virulence of Candida albicans serotype A cells. FEMS Microbiol Lett. 244(2): 373-377.
  • Kaufman D, R Boyle, KC Hazen , JT Patrie, M Robinson, LG Donowitz. 2005. Twice weekly fluconazole prophylaxis for prevention of invasive Candida infection in high-risk infants of <1000 grams birth weight. J. Pediatrics 147: 142-149.
  • Bard M, AM Sturm, CA Pierson, S Brown, KM Rogers, S Nabinger, J Eckstein, R Barbuch, N D Lees, SA Howell, KC Hazen . 2005. Sterol uptake in Candida glabrata : rescue of sterol auxotrophic strains. Diag. Microbiol. Infect. Dis. 52(4): 285-293.
  • Masuoka J, KC Hazen . 2004. Cell wall mannan and cell surface hydrophobicity in Candida albicans serotype A and B strains. Infect. Immun. 72(11): 6230-6236.
  • Singleton DR, KC Hazen . 2004. Differential surface localization and temperature-dependent expression of the Candida albicans CSH1 protein. Microbiology 150: 275-282.
  • Hazen KC. 2004. Environmental influence of cell surface hydrophobicity (CSH) protein expression and CSH-mediated adhesion in Candida dubliniensis. Curr. Microbiol. 48(6): 447-451.  
  • Mathew F, M Mach, KC Hazen, B Fraser-Reid. 2003. Orthoester - based strategy for efficient synthesis of the virulent antigenic β-1,2-linked oligomannans of Candida albicans. Synlett. No. 9: 1
  • Hazen KC, EJ Baron, A Colombo, C Girmenia, A Sanchez-Souza, A del Palacio, C de Bedout, DL Gibbs, and the Global Antifungal Surveillance Group. 2003. A four-year global evaluation of the susceptibility of yeasts to fluconazole by disk diffusion; comparison to voriconazole. J. Clin. Microbiol. 41(12): 5623-5632.


    A more complete list of Dr. Hazen's publications can be obtained from PubMed