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U.VA. RESEARCHERS FINDING MORE EFFECTIVE TREATMENT FOR LUNG CANCER

Making chemotherapy treatment for non-small cell lung cancer more effective and less toxic may eventually be possible, according to results of a study conducted by University of Virginia cancer researchers and published in this month's Journal of Thoracic and Cardiovascular Surgery.

A research team, led by principal investigator Dr. David R. Jones, assistant professor of surgery and a member of the University of Virginia Cancer Center's Thoracic Oncology Program, identified a way of inhibiting a protein, called nuclear factor-kappa B (NF-kB), which chemotherapy activates in lung tumors. Activation of this protein helps make the lung cancers resistant chemotherapy. Jones's research team discovered that the inhibition of NF-kB enhances the ability of chemotherapy to kill lung cancer cells by activating the tumor cell's mitochondria and death enzymes, called caspases.

Inhibition of NF-kB or its associated pro-survival proteins allows the tumor cells to be killed by chemotherapy. As a result, lower doses of chemotherapy can be used, allowing the patient to suffer fewer of the toxic side effects related to the chemotherapy. Although Jones' research is still in its early stages, it may prove to be an important advance for patients with lung cancer - the most common cancer killer worldwide.

This type of cancer is often only diagnosed at a late stage, after spreading throughout the body, and unfortunately is quite resistant to both chemotherapy and radiation, Jones said. Our laboratory results suggest that inhibiting the pro-survival protein NF-kB and/or its gene products may be new mechanism for sensitizing tumor cells to chemotherapy.

Jones was recognized last year by the American Association for Cancer Research for his translational research identifying the role of NF-kB in chemoresistance of lung cancer. This study also received funding from the National Cancer Institute and the American Cancer Society.

February 26, 2002