Biomedical Sciences Graduate Program(s)
Neuroscience
Biochemistry, Molecular Biology and Genetics
Research Description
Our research centers around understanding the molecular basis by which the nervous system is sculpted during development. We use a combination of genetic, biochemical, and mathematical modeling techniques to determine how competition defines proper cell number and synaptic connectivity.
We are also interested in how these competitive developmental programs that are used to assemble the nervous system might be exploited by pathologies such as Alzheimer's and Lou Gerhig's Disease to disassemble the nervous system.
There are several projects that are available which will be scaled for undergrad students, grad students, or post-docs. To learn more about potential research projects,
visit my lab webpage.
Selected Publications
Deppmann, C.D., Mihalas, S., Sharma, N., Lonze, B.E., Niebur, E, Ginty D.D. (2008) A Model for Neuronal Competition During Development. Science, 320(5874) 369-73.
Deppmann, C.D., Ginty D.D. (2006) Retrograde Control of Neural Circuit Formation. Cell 127(7) 1306-7.
Deppmann, C.D., Alvania, R.A., Taparowsky, E.J. (2006) Cross-species Annotation of Basic Leucine Zipper Factor Interactions: Insight Into the Evolution of Closed Interaction Networks. Mol. Biol. Evol. 23(8), 1480-9
Deppmann, C.D., Acharya, A., Rishi, V., Wobbes, B., Smeekens, S., Taparowsky, E.J., Vinson, C. (2004). Dimerization Specificity of All 67 B-ZIP Motifs in Arabidopsis thaliana: A Comparison to Homo sapiens B-ZIP Motifs. Nuc. Acids Res . 32(11), 3435-45.
Intranet Profile
| Contact Information |
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Office Address: |
PO Box 400328, Biology Department, Gilmer Hall, |
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Office Phone: |
+1 434-982-5474 |
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Fax Phone: |
+1 434-982-5626 |
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Home Phone: |
+1 443-799-3415 |
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