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Edward  H.  Bertram  ,III
Degree(s): M.D.
Graduate School: University of North Carolina
Primary Appointment: Clinical Professor of Neurology
Research Interests:
Studies of various aspects of epilepsy using anatomy and in vivo and in vitro physiology.

Email Address: ehb2z@virginia.edu
Biomedical Sciences Graduate Program(s)
  • Neuroscience
    • Research Description

    This laboratory is using a new animal model of chronic limbic epilepsy to investigate the natural history of untreated epilepsy. This study will provide the basis for examining a variety of factors which may affect long-term outcome. In addition, the functional anatomy of limbic seizures is under investigation to determine which brain regions are critical to the generation of spontaneous seizures. These studies include the evaluation of physiologic and anatomic interactions among these areas to determine how normal function and connectivity may be altered to achieve this pathologic state. Clinical investigation centers on the evaluation of patients for surgical treatment of intractable epilepsy, concentrating on improving monitoring and imaging techniques that will better localize the epileptogenic region. These studies involve investigators from neurosurgery, neuroradiology, neuropathology, neuropsychology, and biomedical engineering.

    Selected Publications
  • Bertram EH, Williamson JM, Cornett JC, Spradlin S, and Chen ZF. Design and construction of a long-term continuous video-EEG monitoring unit for simultaneous recording of multiple small animals. Brain Research Protocols 2:85-97, 1997.
  • Mangan PS and Bertram EH. Ontogeny of altered synaptically mediated responses of CA1 pyramidal cells in a model of limbic epilepsy. Brain Research 799:183-196, 1998.
  • Bertram EH, Zhang DX, Mangan PS, Fountain N, and Rempe D. Functional anatomy of limbic epilepsy: A proposal for central synchronization of a diffusely hyperexcitable network. Epilepsy Research 32:194-205, 1998.
  • Bertram EH and Zhang DX. Thalamic excitation of hippocampal CA1 neurons: A comparison with the effects of CA3 stimulation. Neuroscience 92:15-26, 1999.
  • PubMed Listings for this Faculty Member
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    Contact Information
      Office Address: PO Box 800394, Medical School, 
      Office Phone: +1 434-924-5233
      Fax Phone: +1 434-982-1726
      Home Phone: +1 434-971-8402

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