Bradley W. Kesser, M.D.
Assistant Professor
Department of Otolaryngology-Head and Neck Surgery
Education
B.S. Princeton University, 1988
M.D. University of Virginia 1993
Internship/Residency University of Virginia 1995-1999
Fellowship House Ear Clinic 1998-2000
Following my fellowship in Otology-Neurotology at the House Ear Clinic in Los Angeles, I joined a private practice otolaryngology group in Atlanta, GA. I returned to Charlottesville as a faculty member in the Department of Otolaryngology-Head and Neck Surgery in July, 2004. I have been collaborating with the Holt lab in the development of an in vitro model system to study gene therapy in the human vestibular epithelium. I and my colleague, George Hashisaki in the Otolaryngology Department, harvest the ampullae of the semicircular canals and the maculae of the utricle and saccule in patients undergoing surgical labyrinthectomy either for vestibular schwannoma resection or for Meniere's Disease. The human tissue is placed in tissue culture and transfected with various recombinant adenoviral vectors, and reporter gene expression is observed. We have also transfected the human tissue with an adenoviral vector containing the gene for KCNQ4, a potassium channel gene whose mutation causes sensorineural hearing loss (DFNA2). We have demonstrated that human vestibular tissue can be cultured and transfected with adenoviral vectors, and these vectors can drive expression of exogenous protein. Future studies will look at expression of other genes inserted into adenoviral vectors in our model of the human inner ear.
Contact information
Email: bwk2n@virginia.edu
Office: (434) 924-2040
Fax: (434) 982-3965
Mailing Address
University of Virginia
Department of OTO-HNS
Box 800713
Charlottesville, VA 22908-0713
Delivery Address
University of Virginia
Dept. OTO-HNS
1 Hospital Drive
2nd Floor - Old Medical School, Rm. 2744
Charlottesville, VA 22908
Holt / Géléoc Lab Home
