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Alzheimer's Disease Research Center and related Disorders
- diagnostic and treatment aspects of dementia
- cognitive and neurobiologic conceptualizations of memory
- longitudinal study of dementia
- studies of electron transport chain dysfunction in human tissue
- effects of glucose and aging on cognition
- Clinical Trials: ENA713-B353, ENA713-B355, ENA713-B356, tacrine GITS, metrifonate (MINT)
Comprehensive Stroke Program / Cerebrovascular Disease
- Central Registry for the International Cooperative Aneurysm Study
- diagnostic and treatment aspects of ischemic stroke, and subarachnoid and intracerebral hemorrhage
- clinical trial methodology and statistics
- stroke awareness community and professional education program
- Clinical Trials: GV150526 (GAIN AMERICAS), SB214857, aspirin versus ticlopidine in African Americans, t-PA and lubeluzole
Neuro Critical Care
- intracranial hemodynamics
- intracranial pressure control
- mechanisms of encephalopathy in sepsis
- epidemiology and prognosis of critical systemic illness
- neurogenic respiratory failure
- pharmacologic treatment of status epilepticus
- mechanisms of coma
- Clinical Trials: drug therapy in head trauma, stroke trials
F. E. Dreifuss Comprehensive Epilepsy Program
- functional MRI localization of motor and speech cortex
- electrophysiologic studies using intracranial microelectrodes
- development of an epilepsy patient database
- chronobiology of epilepsy
- quantitative neuroimaging in epilepsy patients
- epilepsy surgery outcomes
- Clinical Trials: lamotrigine, vigabatrin, zonisamide, SK204269, UCBL059, vagus nerve stimulation for generalized seizures, prospective study of psychotherapy for pseudoseizures
Huntington's Disease Program
- Huntington's Study Group Database - A natural history of Huntington's disease (longitudinal clinical data collection)
- genetic counseling for Huntington's disease
- multidisciplinary Huntington's disease clinic
- Clinical Trials:co-enzyme Q10 and remacemide
Neuromuscular Disease Center
- epidemiology of myasthenia gravis
- treatment strategies in "stiff-man syndrome"
- intraoperative neurophysiologic recordings in tethered spinal cord
- application of electrodiagnostic techniques to the study of movement disorders
- Clinical Trials: IVIG in chronic inflammatory demyelinating polyneuropathy (CIDP), IVIG in myasthenia gravis, nerve growth factor (NGF) in diabetic neuropathy
Parkinson's Disease / APDA Center of Excellence
- studies of electron transport chain dysfunction in human tissue
- establishment of a center for patient education, information, and referral
- effects of manipulating circulating blood glucose levels on cognition in Parkinson's disease
- epidemiological studies of Parkinson's disease
- studies of familial Parkinson's disease
- clinical database for longitudinal studies of disease progression and treatment complications
- Clinical Trials: PNU-95666E, pramipexole, intracerebroventricular r-metHuGDNF, IV pramipexole, comparison of pramipexole and carbidopa/levodopa, early versus late L-dopa, biopterin and phenylalanine metabolism in patients with dopa- responsive dystonia
Pediatric Neurology
- Clinical Trials: UCBL059 (levetiracetam) for childhood seizures
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