Division of Nephrology and
Center for Immunity, Inflammation and Regenerative Medicine
2007-2008
Abdel-Rahman EM, Abadir PM, Siragy HM. Regulation of renal 12(S)-hydroxyeicosatetraenoic acid in diabetes by angiotensin AT1 and AT2 receptors. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1473-8. Epub 2008 Sep 17.
Awad AS, Okusa MD. Distant organ injury following acute kidney injury. Editorial Comment. Am J Physiol Renal Physiol. 2007;293:F28-F29.
Awad A, Rouse M, Huang L, Vergis AL, Reutershan J, Linden J, Okusa MD. Neutrophil transmigration following kidney ischemia-reperfusion injury. Kidney Int. (with commentary) In press, 2008.
Awad AS, Rouse M, Liu L, Vergis AL, Rosin DL, Linden J, Sedor J, Okusa MD. Activation of 2A receptors preserves structure and function of podocytes. J Am Soc Nephrol. 2008 Jan;19:59-68.
Balogun R, Abdel-Rahman EM. Successful maintenance hemodialysis in nonagenarians with end-stage renal disease and pre-existing comorbidities. J Am Soc Geriatr. In press, 2008.
Baruch M, Kwon K, Abdel-Rahman EM, Isaacs R. The structure of the radial pulse - a novel non-invasive ambulatory blood pressure device. Chapter in: Studies in Health Technology and Informatics. Ed. Westwood JD, Haluck RS, Hoffman HM et al. Volume 125, 2007.
Beaty SR, Rose CE Jr, Sung, S-S J. Diverse and potent chemokine production by lung CD11b high dendritic cells in homeostasis and in allergic lung inflammation. J Immunol. 2007;178:1882-1895.
Bissram M, Scott FD, Liu L, Rosner MH. Risk factors for symptomatic hyponatraemia: the role of pre-existing asymptomatic hyponatraemia. Intern Med J. 2007;37:149-155.
Brown MG, Dighe A, Rodriguez M, Xie X. NK cells: Innate sensors and effectors of virus immunity distinguished by genetic diversity. In Everything You Always Wanted to Know About NK Cells But Were Afraid to Ask. Ed. Laurent Brossay, Transworld Research Network. In press, 2007.
Brown MG, Scalzo AA. NK gene complex dynamics and selection for NK cell receptors. Semin Immunol. 2008;20:361-8 (in press). Epub 2008 Jul 18.
Campbell GA, Rosner MH. The agony of ecstasy: MDMA (3,4-methylenedioxymethamphetamine) and the kidney. Clin J Am Soc Nephrol. 2008;3:1852-1860.
de Queiros MGJ, Silva DAO, Alves R, Chiba HF, de Amaral VBS, de Almeida KC, Ynoue LH, de Oliveira Resende R, Soplete MC, Segindo GRS, de Sousa Moreira PF, Sung SJ, Taketomi EA. Mite-specific immunotherapy using allergen and/or bacterial extracts in atopic patients in Brazil. J Investig Allergol Clin Immunol. 2008;18:84-92.
Deshmukh US, Bagavant H, Sim D, Pidiyar V, Fu SM. SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleo protein complex than to SmD protein via intermolecular epitope spreading. J. Immunol. 2007;178:2565-2571.
Deshmukh US, Nandula SR, Thimmalapura PR, Scindia YM, Bagavant H. Activation of innate immune responses through toll-like receptor 3 causes a rapid loss of salivary gland function. J Oral Pathol Med. In press, 2008.
Deshmukh US, Ohyama Y, Bagavant H, Guo X, Gaskin F, Fu SM. Inflammatory stimuli accelerate Sjogren's syndrome-like disease in NZB/WF1 mice. Arthritis Rheum. 2008;58:1318-1323.
Du P, Wood KM, Rosner MH, Cunningham D, Tate B, Geoghegan KF. Dominance of amyloid precursor protein sequence over host cell secretases in determining beta-amyloid profiles studies of interspecies variation and drug action by internally standardized immunoprecipitation/mass spectrometry. J Pharmacol Exp Ther. 2007;320:1144-1152.
Ellison DH, Okusa MD, Schrier RW. Mechanisms of diuretic action. In Diseases of the Kidney. Ed. R.W. Schrier. Lippincott, 2007.
Foss FW Jr, Snyder AH, Davis MD, Rouse M, Okusa MD, Lynch KR, Macdonald TM. Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorg Med Chem. 2007;15:663-677.
Hew-Butler T, Ayus JC, Kipps C, Maughan RJ, Mettler S, Meeuwisse WH, Page AJ, Reid SA, Rehrer NJ, Roberts WO, Rogers IR, Rosner MH, Siegel AJ, Speedy DB, Stuempfle KJ, Verbalis JG, Weschler LB, Wharam P. Statement of the Second International Exercise-Associated Hyponatremia Consensus Development Conference, New Zealand, 2007. Clin J Sport Med. 2008;18:111-121.
Himmelfarb J, Joannidis M, Molitoris B, Schietz M, Okusa MD, Warnock D, Laghi F, Goldstein SL, Prielipp R, Parikh C, Pannu N, Lobo SM, Shah S, D'Intini V, Kellum JA. Evaluation and initial management of acute kidney injury. C. J Am Soc Nephrol. 2008;3:962-967.
Jo SK, Bajwa A, Awad AS, Lynch K, Okusa MD. Invited review. Sphingosine 1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney Int. 2008;73:1220-1230.
Jo SK, Bajwa A, Ye H, Kharel Y, Lynch K, Okusa MD. Role of sphingosine kinases in ischemia-reperfusion injury. Kidney Int. In press, 2008. *Equal contributions as first author.
Jo SK, Bajwa A, Ye H, Vergis A, Awad AS, Kharel Y, Lynch KR, Okusa MD. Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney Int. In press, 2008.
Jo SK, Rosner MH, Okusa MD. Pharmacologic treatment of acute kidney injury: why drugs haven't worked and what is on the horizon. Clin J Am Soc Nephrol. 2007;2:356-365.
Kalantarinia K, Okusa MD. Ultrasound contrast agents in the study of kidney function in health and disease. Drug Discovery Today: Disease Mechanisms. 2007;4:153-158.
Keepers TR, Gross LK, Obrig TG. Monocyte chemoattractant protein 1, macrophage inflammatory protein 1 alpha, and RANTES recruit macrophages to the kidney in a mouse model of hemolytic-uremic syndrome. Infect Immun. 2007;75:1229-1236.
Keith D, Ashby VB, Port FK, Leichtman AB. Insurance type and minorities associated with large disparities in prelisting dialysis exposure among candidates for kidney transplantation. Clinical J Am Soc Nephrol. 2008;3:463-470.
Keith DS, Cantarovich M, Paraskevas S, Tchervenkov J. Duration of dialysis pre-transplantation is an important risk factor for delayed recovery of renal function following decease donor kidney transplantation. Transpl Int. 2008;21:126-32. Epub 2007 Oct 17.
Kinsey GR, Li L, Okusa MD. Inflammation in acute kidney injury. Invited Review. Nephron Exp Nephrol. 2008;109:e102-7.
Kolling GL, Obata F, Gross LK, Obrig TG. Immunohistologic techniques for detecting the glycolipid Gb(3) in the mouse kidney and nervous system. Histochem Cell Biol. 2008;130:157-164.
Leichtman AB, Cohen D, Keith D, O'Connor K, Goldstein M, McBride V, Gould CJ, Christensen LL, Ashby VB. Kidney and pancreas transplantation in the United States, 1997-2006; the HRSA Breakthrough Collaboratives and the 58 DSA Challenge. Am J Transplant. In press, 2008.
Li L, Huang L, Sung S, Lobo P, Brown MG, Gregg RK, Engelhard VH, Okusa MD. NKT cell activation mediates neutrophil interferon gamma production and renal ischemia-reperfusion injury. J Immunol. 2007;178:5899-5911.
Li L, Huang L, Sung S-S J, Vergis AL, Rosin DL, Rose C Jr, Lobo PI, Okusa MD. The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury. Kidney Int. 2008;74:1526-1537. (Editorial Commentary: S. Swaminathan and M. D. Griffin) Kidney Int. 2008;74:1509-1511.
Lobo P, Schlegel KH, Spencer CE, Okusa MD, Chisolm C, Mchedlishvili N, Park A, Christ C, Burtner C. Naturally occurring IgM anti-leukocyte autoantibodies (IgM-ALA) inhibit T cell activation and chemotaxis. J Immunol. 2008;180:1780-1791.
Lobo P, Schlegel KH, Yuan W, Townsend GC, White JA. Inhibition of HIV-1 infectivity through an innate mechanism involving naturally occurring IgM anti-leukocyte autoantibodies. J Immunol. 2008;180:1769-1779.
Mangrum AJ, Okusa MD. Invited review. Mechanisms of vascular access dysfunction. Drug Discovery Today: Disease Mechanism. 2007;4:147-151.
McCulloch M, Brooks H, Kalantarinia K. Isolated polyarticular septic arthritis, an atypical presentation of meningococcal infection. Am J Med Sci. 2008;335:323-326.
Molitoris BA, Melnikov VY, Okusa MD, Himmelfarb J. Technology insight: biomarker development in acute kidney injury-what can we anticipate? Nature Clin Pract Nephrol.2008;4:154-165.
Naiman N, Baird BC, Isaacs RB, Koford JK, Habib AN, Wang BJ, Barenbaum LL, Goldfarb-Rumyantzev AS. Role of pre-transplant marital status in renal transplant outcome. Clin Transplant. 2007;21:38-46.
Northup PG, Sundaram V, Fallon MB, Reddy KR, Balogun RA, Sanyal AJ, Anstee QM, Hoffman MR, Ikura Y, Caldwell SH. Coagulation in liver disease group. Hypercoagulation and thrombophilia in liver disease. J Thromb Haemost. 2008;6:2-9.
Obata F, Tohyama K, Bonev AD, Kolling GL, Keepers TR, Gross LK, Nelson MT, Sato S, Obrig TG. Shiga toxin 2 affects the central nervous system through receptor globotriaosylceramide localized to neurons. J Infect Dis. 2008;198:1398-1406.
Okusa MD. Adenosine 2A receptors in acute renal failure. In Critical Care Nephrology, Ed. C. Ronco and R. Bellomo. Kluwer Academic Publishers. In Press, 2008.
Okusa MD, Lynch KR. Invited review. Targeting sphingosine 1 phosphate receptor type 1 receptors in acute kidney injury. Drug Discovery Today: Disease Mechanism. 2008;4:55-59.
Ranpura SA, Deshmukh US, Reddi PP. NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription. J Androl 2007;107.003756v1.
Roche JK, Keepers TR, Gross LK, Seaner RM, Obrig TG. CXCL1/KC and CXCL2/MIP-2 are critical effectors and potential targets for therapy of Escherichia coli O157:H7-associated renal inflammation. Am J Pathol. 2007;170:526-37.
Roche JK, Stone MK, Gross LK, Lindner M, Seaner R, Pincus SH, Obrig TG. Post-exposure targeting of specific epitopes on ricin toxin abrogates toxin-induced hypoglycemia, hepatic injury, and lethality in a mouse model. Lab Invest. 2008;88:1178-91.
Rosner MH. Measuring risk in end-stage renal disease: is N-terminal pro brain natriuretic peptide a useful marker? Kidney Int. 2007;71:481-483.
Rosner MH, Bolton WK. Addictions in Medicine: Principles and Practices (Miller NS, Gold MS, Eds.) Chapter 24: Addictions in Renal Diseases. In press, 2007.
Rosner MH, Bolton WK. Membranous Nephropathy. Diseases of the Kidney and Urinary Tract. R. Schrier, Ed. Lippincott Williams Wilkins, Philadelphia PA, 8th ed. 2007, pp 1568-1585.
Rosner MH, Bolton WK. The mortality risk associated with higher hemoglobin: is the therapy to blame? Kidney Int. 2008;74:695-7.
Rosner MH, Kirven J. Exercise-associated hyponatremia. Clin J Am Soc Nephrol. 2007;2:151-161. Epub 2006 Nov 29. Review.
Rosner MH, Portilla D, Okusa MD. Analytic Reviews: Cardiac surgery as a cause of acute kidney injury: pathogenesis and potential therapies. J Intensive Care Med. 2008;23:3-18.
Rosner MH, Okusa MD. Drug-associated acute renal failure in the intensive care unit. In Clinical Nephrotoxins - Renal Injury from Drugs and Chemicals. 3rd edition Marc E. De Broe, George A. Porter, William M. Bennett and Gilbert Deray. Kluwer Academic Press. In press, 2008.
Rosner MH, Okusa MD. Editors, in Biomarkers in Renal Disease. Nova Science Publishers, Inc. United Kingdom, 2008.
Schwartz S, Williams ME, Arauz C, Bolton WK. Phase I study of FG-3019, an anti-CTGF monoclonal antibody, in Type ½ diabetes mellitus with microalbuminuria. Diabetes 2007;56:A151-A151 Supp 1.
Scindia YM, Deshmukh US, Thimmalapura PR, Bagavant H. Anti-alpha 8 integrin immunoliposomes: A novel system for delivery of therapeutic agents to the renal glomerulus in systemic lupus erythematosus. Arthritis Rheum. In press, 2008.
Sevigny CP, Li L, Awad AS, Huang L, McDuffie M, Linden J, Lobo PI, Okusa MD. Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition. J Immunol. 2007;178:4240-4249.
Sharma A, Fernandez L, Awad AS, Kron I, Laubach V. Proinflammatory response of alveolar epithelial cells is enhanced by alveolar macrophage-produced TNF-alpha during pulmonary ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2007;293:L105-13.
Sharma R, Jarjour WN, Zheng L, Gaskin F, Fu SM, Ju ST. Large functional repertoire of regulatory T cell suppressible autoimmune T cells in scurfy mice. J Autoimmun. 2007;29:10-19. (#1 most downloaded research paper (excluding reviews) for the third quarter of 2007 of the Journal).
Sharma R, Ju AC, Kung JT, Fu SM, Ju ST. Rapid and selective expansion of nonclonotypic T cells in regulatory T cell-deficient, foreign antigen-specific TCR-transgenic scurfy mice: antigen-dependent expansion and TCR analysis. J Immunol. 2008;181:6934-6941.
Sharma R, Rosner MH. Glucose in the dialysate: historical perspective and possible implications? Review. Hemodial Int. 2008;12:221-226.
Sharma R, Zheng L, Deshmukh US, Jarjour WN, Sung SS, Fu SM, Ju ST. Cutting edge: a regulatory T cell-dependent novel function of CD25 (IL-2Ra) controlling memory CD8+ T cell homeostasis. J Immunol. 2007;178:1251-1255.
Shusterman B, Mchedishvili G, Rosner MH. Outcomes for hepatorenal syndrome and acute kidney injury in patients undergoing liver transplantation: a single-center experience. Transplant Proc. 2007;39:1496-1500.
Simplicio EC, Silva DAO, Braga IA, Soplete MC, Sung SJ, Taketomi EA. Mite and pet allergen exposure in hotels in Uberlandia, Midwestern Brazil. Indoor Air. 2007;17: 278-283.
Stone MK, Kolling GL, Lindner MH, Obrig TG. p38 mitogen-activated protein kinase mediates lipopolysaccharide and tumor necrosis factor alpha induction of shiga toxin 2 sensitivity in human umbilical vein endothelial cells. Infect Immun. 2008;76:1115-1121.
Sung S-S J. Monocyte-derived dendritic cells as antigen-presenting cells in T-cell proliferation and cytokine production. In Methods in Molecular Medicine: Allergy Methods and Protocols. Vol. 138; Eds., Jones, M.G. and Lympany, P. pp. 97-106, Humana Press Inc., Totowa, NJ, 2008.
Williams ME, Bolton WK, Khalifah RG, Degenhardt TP, McGill J. Effects of pyridoxamine in combined phase 2 studies of patients with Type 1 and Type 2 diabetes and overt nephropathy. Am J Nephrol. 2007;27:605-614.
Xie X, Dighe A, Clark P, Sabastian P, Buss S, Brown MG. Deficient MHC-linked innate murine CMV immunity in MA/My.L-H2b mice and viral down-regulation of H-2k class I proteins. J Virol. 2007;81:229-236.
Yoon HS, Legge KL, Sung SS, Braciale TJ. CD8+ T cells sequentially enter the draining lymph nodes and activate in response to pulmonary virus infection. J Immunol. 2007;179:391-399.
Zhang W, Sharma R, Ju S-T, He XS, Tao Y, Tsuneyama K, Tian Z, Lian ZX, Fu SM and Gershwin ME. Deficiency in regulatory T cells results in development of antimitochondrial antibodies and autoimmune cholangitis. Hepatology. 2008 (epub Sep 22, 2008).
Zheng L, Sharma R, Gaskin F, Fu SM, Ju ST. A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms. J Immunol. 2007;179:8035-8041.
Zheng L, Sharma R, Kung JT, Deshmukh US, Jarjour WN, Fu SM, Ju ST. Pervasive and stochastic changes in the TCR repertoire of regulatory T cell-deficient mice. Int Immunol. 2008;20:517-523. Epub 2008 Feb 28.