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Peter I. Lobo, M.D. Associate Professor of Medicine Department of Medicine, Division of Nephrology
M.D., 1966: Makerere University, Uganda |
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Phone 434-924-5125 | Fax 434-924-5848 | Email pil@virginia.edu |
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My basic research involves investigating the role of naturally occurring IgM anti-lymphocyte autoantibodies (IgM-ALA) in regulating inflammatory processes and in inhibiting entry of HIV-1 and Hepatitis C into cells. We have shown that these IgM-ALA comprise a heterogeneous group of IgM antibodies with specificity for CD3, CD4, CD81, CCR5 and CXCR4. In in-vitro studies, we show that IgM-ALA inhibits T cell activation, leucocyte chemotaxis and inhibits HIV-1 infectivity of cells. Our current plans are to develop in-vivo murine models of allograft rejection and renal ischaemia reperfusion injury to test the in-vivo anti-inflammatory role of IgM-ALA. We also plan to do studies on HIV-1 patients to determine if there is a correlation between levels of certain IgM-ALA and disease progression. My clinical research involves understanding microchimerism and transplant tolerance. PubMed Search for articles by faculty member » References Lobo P, Schlegel KH, Spencer CE, Okusa MD, Chisolm C, Mchedlishvili N, Park A, Christ C, Burtner C. Naturally occurring IgM anti-leukocyte autoantibodies (IgM-ALA) inhibit T cell activation and chemotaxis. J Immunol. 2008;180:1780-1791. Li L, Huang L, Sung SS, Lobo PI, Brown MG, Gregg RK, Engelhard VH, Okusa MD. NKT cell activation mediates neutrophil IFN-gamma production and renal ischemia-reperfusion injury. J Immunol. 2007;178:5899-5911. Sevigny CP, Li L, Awad AS, Huang L, McDuffie M, Linden J, Lobo, PI, Okusa MD. Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition. J Immunol 2007;178:4240-4249. Hu DC, Burtner C, Hong A, Lobo PI, Okusa MD. Correction of renal hypertension after kidney transplantation from a donor with Gitelman syndrome. J Med Sciences. 2006;331:105-109. |