University of Virginia Health System

M.D., 1969:  University of Virginia
Residency:  Boston City Hospital, Harvard Medical School
Fellowship:  Pritzker School of Medicine
Certification:  Internal Medicine 1972, Nephrology 1974

Phone 434-924-5125  |  Fax 434-924-5848  |  Email wkb5s@virginia.edu

My interests are in the areas of molecular dissection of the epitopes involved in Goodpasture's syndrome, the role of T regulatory cells in disease modification, and in chronic kidney disease (CKD). My experimental work involves a rat model of Goodpasture's disease which can be induced with a single peptide which induces intra- and intermolecular epitope spreading on GBM antigens. I am involved in clinical trials to slow progression of kidney disease, prevent complications of CKD, and better prepare patients for renal replacement therapy.

My professional activities include:  involvement in numerous Clinical Practice Guideline work groups in kidney diseases; serving as a Board member of the Renal Physicians Association (RPA) which is dedicated to improving the quality of the clinical practice of Nephrology, and chairing the Clinical Practice Committee of the RPA; and participating in numerous activities in the American Society of Nephrology and the National Kidney Foundation.

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References

Chen L, Hellmark T, Pedchenko V, Hudson BG, Pusey CD, Fox JW, Bolton WK. A nephritogenic peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune glomerulonephritis. J Am Soc Nephrol. 2006;17(11):3076-3081.

Bolton WK, Chen L, Hellmark T, Wieslander J, Fox JW. Epitope Spreading and Autoimmune Glomerulonephritis in Rats Induced by a T-cell Epitope of Goodpasture's Antigen. J Am Soc Nephrol. 2005;16(9):2657-2666.

Chen L, Hellmark T, Wieslander J, Bolton WK. Immunodominant epitopes of a3(IV)NC1 induce autoimmune glomerulonephritis in rats. Kidney Int. 2003;64(6):2108-2120.

Hellmark T, Chen L, Ohlsson S, Wieslander J, Bolton WK. Point mutations of single amino acids abolish ability of a3 NC1 domain to elicit experimental autoimmune glomerulonephritis in rats. J Biol Chem. 2003;278(47):46516-46522.

Luo AM, Fox JW, Chen L, Bolton WK. Synthetic peptides of Goodpasture's antigen in anti-glomerular basement membrane nephritis in rats. J Lab Clin Med. 2002;139(5):303-310.