University of Virginia Health System

RECENT PAPERS FROM THE LAB

RECENT REVIEWS

o  Okusa, M.D. A2A-adenosine receptors. Novel target for therapeutic intervention in renal disease. Invited Review, Am J. Physiol. (Renal) 282: F10-F18, 2002. PubMed

o  Okusa, M.D. The inflammatory cascade of acute ischemic renal failure.  Invited Review. Distinguished Scientists Lecture Series. Nephron. 90:133-138, 2002. PubMed

o  L. Li and Okusa, M.D. Blocking the immune response in ischemic acute kidney injury. Nat. Clin. Pract. Nephrol. 2: 432-444, 2006. PubMed

o  Rosner, M.H. and Okusa, M.D. Acute kidney injury associated with cardiac surgery. Clin. J. Am.Nephrol. 1:19-32, 2006. PubMed

o  Jo, S.K. Rosner, M.H. and Okusa, M.D. Pharmacologic treatment of acute kidney injury. Clin. J. Am.Soc. Nephrol. 2: 356 – 365, 2007. PubMed

o  Molitoris, B.A.  V.Y. Melnikov, M.D. Okusa and J. Himmelfarb.  Technology Insight: biomarker development in acute kidney injury—what can we anticipate? Nature Clin. Pract. Nephrol. Nature Clin. Pract. Nephrol. 4, 154-165, 2008 

o Jo. S. K, A. Bajwa, A. Awad, K. Lynch and M.D. Okusa. Invited review. Sphingosine 1-phosphate Receptors:  Biology and Therapeutic Potential in Kidney Disease. Kidney Int. Kidney Int. 73, 1220-1230, 2008. PubMed  

o Kinsey, G.R., Li, L., M.D. Okusa. Inflammation in acute kidney injury. Invited Review. Nephron 2008 in press 

RECENT PAPERS

o  Okusa, M.D., Hong Ye, Liping Huang, Laura Sigismund, Timothy Macdonald and Kevin R. Lynch. Selective Blockade of Lysophosphatidic Acid LPA3 Receptors Reduces Murine Renal Ischemia-Reperfusion Injury. Am.J.Physiol. 285(3):F565-74, 2003. PubMed

o  Yuan-Ji Day, Liping Huang, Marcia J. McDuffie, Diane L. Rosin, Hong Ye, Michael A. Schwarzschild, J. Stephen Joel Linden and M. D. Okusa. Renal Protection from Ischemia Mediated by A2A Adenosine Receptors on bone marrow-derived Cells. J. Clin. Invest. 112: (6):883-91, 2003. PubMed

o  Day, Y.J. M. Marshall, L. Huang, H. Ye, J. Linden and M. D. Okusa. Renal Ischemia-Reperfusion Injury and Adenosine 2A Receptor-Mediated Tissue Protection: The Role of Macrophages. Am J Physiol Renal Physiol. 2005 Apr;288(4):F722-31. PubMed

o  Awad, A.S., H. Ye, L. Huang, M. Davis, K. Lynch and M.D. Okusa. Selective sphingosine 1 phosphate receptor activation reduces ischemia-reperfusion injury. Am J Physiol Renal Physiol, 290:F1516-F1524, 2006. PubMed

o  Awad, A.S. L. Huang, H. Ye, E. T. A. Duong, W. K. Bolton, J.Linden and M. D. Okusa. Adenosine A2A Receptor Activation Attenuates Inflammation and Injury in Diabetic Nephropathy. Am J Physiol Renal Physiol, 290: F828-837, 2006. PubMed

o  Sevigny, C.P*. L. Li*, A. S. Awad, L. Huang, M.McDuffie, J. Linden, P. I. Lobo and M. D. Okusa. Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition. J Immunol. 178(7):4240-4249, 2007. * Share first authorship. PubMed

o  Li, L. L. Huang, S.S.J. Sung, P.I. Lobo, M.G. Brown, R.K.Gregg, V.H. Engelhard and M.D. Okusa. NKT cell activation mediates neutrophil interferon gamma production and renal ischemia-reperfusion injury. J. Immunol. 178:5899-5911, 2007 PubMed

o Awad, A.S., M. Rouse, L. Liu, A. L. Vergis, D. L. Rosin, J. Linden, J. R. Sedor and M. D. Okusa.  Activation of podocyte adenosine 2A receptors prevents puromycin-induced nephrosis.  J. Am. Soc. Nephrol. 19: 59-68, 2008. PubMed

o  Himmelfarb, J.,  M. Joannidis MD, B. Molitoris, M. Schietz, M.D. Okusa, D. Warnock, F. Laghi MD, S. L. Goldstein, R. Prielipp, C. Parikh, N. Pannu, S. M. Lobo, S. Shah,V. D’Intini, J. A. Kellum. Evaluation and Initial Management of Acute Kidney Injury.  C.  J. Am. Soc. Nephrol.  3:962-7, 2008 PubMed

o Jo. S.-K,  Bajwa, A.*, Hong Ye, Y. Kharel, K. Lynch and M.D. Okusa. Divergent roles of sphingosine kinases in ischemia-reperfusion injury. In press Kidney Int. 2008. *Equal contributions as first author. PubMed