cancer

Search this Site
Keywords or Phrases View the Site Index

Signaling and Cancer

The goal is to understand cell signaling as a three dimensional process, organized and expedited by an array of cytoskeletal structures, receptor complexes, adapter proteins and targeting molecules. We focus on receptor mediated signaling, propagation and regulation of signals in the cytoplasm, and regulatory circuits including gene expression, DNA synthesis and cell cycle regulation.

Recent Research		Program Projects
MAP kinase signaling Adhesion signaling Src and intracellular signaling pathways Ran, a GTPase for nuclear protein export T cell signaling and development Visualization of nuclear transcription and splicing Regulation of membrane exocytosis	Regulation of chromatin structure in yeast DNA replication & amplification Therapeutic resistance in breast cancer Prostate cancer signaling Tumor immunology Targeted Therapies	Prostate Cancer Signaling Signal Transduction in Time and Space Histone modification and genetic stability

Microbiology Primary Faculty
Timothy P. Bender, Ph. D. Professor of Microbiology Regulation of gene expression during lymphocyte development David L. Brautigan, Ph.D. Professor of Microbiology Protein Ser/Thr Phosphatases in Cell Signaling and Cell Cycle Loren D. Erickson, Ph.D. Assistant Professor of Microbiology Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus and multiple myeloma; Immunotherapeutics in the treatment of B cell disorders Deborah A. Lannigan, Ph.D. Associate Professor of Microbiology Kinases, Drugs and Breast Cancer Ian G. Macara, Ph.D. Professor of Microbiology Mechanisms of Cell Polarity Establishment and Nuclear Transport J. Thomas Parsons, Ph.D. Professor and Chair of Microbiology Adhesion Signaling in Normal, Cardiovascular and Cancer Cells Lucy F. Pemberton, Ph.D. Associate Professor of Microbiology Nuclear Transport in Chromatin Assembly and Transcriptional Regulation Kodi S. Ravichandran, B.V.Sc., Ph.D. Professor of Microbiology Intracecellular signaling in lymphocytes and phagocytes Michael J. Weber, Ph.D. Professor of Microbiology Signal Transducing Kinases in Cancer	Amy H. Bouton, Ph.D. Professor of Microbiology Signaling Pathways that Regulate Tumor Growth, Metastasis, and Response to Anticancer Agents; Adhesion Signaling In Macrophages; Bacteria-Host Cell Interactions Daniel A. Engel, Ph.D. Associate Professor of Microbiology Transcriptional Regulation in Cancer Cells Marie-Louise Hammarskjold, M.D., Ph.D. Professor of Microbiology Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses Ulrike M. Lorenz, Ph.D. Associate Professor of Microbiology Involvement of the protein tyrosine phosphatase SHP-1 in signal transduction pathways David W. Mullins, Ph.D. Assistant Professor of Microbiology Immunotherapy; Tumor Immunology Sarah (Sally) J. Parsons, Ph.D. Professor of Microbiology Molecular mechanisms of Src family tyrosine kinases in mitogenesis, tumorigenesis, and neuronal activity. Martin A. Schwartz, Ph.D. Professor of Microbiology Integrin Signaling and Its Relevance to Mechanotransduction, Cancer and Vascular Disease

Microbiology Primary Faculty

Timothy P. Bender, Ph. D.
Professor of Microbiology
Regulation of gene expression during lymphocyte development
David L. Brautigan, Ph.D.
Professor of Microbiology
Protein Ser/Thr Phosphatases in Cell Signaling and Cell Cycle
Loren D. Erickson, Ph.D.
Assistant Professor of Microbiology
Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus and multiple myeloma; Immunotherapeutics in the treatment of B cell disorders
Deborah A. Lannigan, Ph.D.
Associate Professor of Microbiology
Kinases, Drugs and Breast Cancer
Ian G. Macara, Ph.D.
Professor of Microbiology
Mechanisms of Cell Polarity Establishment and Nuclear Transport
J. Thomas Parsons, Ph.D.
Professor and Chair of Microbiology
Adhesion Signaling in Normal, Cardiovascular and Cancer Cells
Lucy F. Pemberton, Ph.D.
Associate Professor of Microbiology
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Kodi S. Ravichandran, B.V.Sc., Ph.D.
Professor of Microbiology
Intracecellular signaling in lymphocytes and phagocytes
Michael J. Weber, Ph.D.
Professor of Microbiology
Signal Transducing Kinases in Cancer

Amy H. Bouton, Ph.D.
Professor of Microbiology
Signaling Pathways that Regulate Tumor Growth, Metastasis, and Response to Anticancer Agents; Adhesion Signaling In Macrophages; Bacteria-Host Cell Interactions
Daniel A. Engel, Ph.D.
Associate Professor of Microbiology
Transcriptional Regulation in Cancer Cells
Marie-Louise Hammarskjold, M.D., Ph.D.
Professor of Microbiology
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Ulrike M. Lorenz, Ph.D.
Associate Professor of Microbiology
Involvement of the protein tyrosine phosphatase SHP-1 in signal transduction pathways
David W. Mullins, Ph.D.
Assistant Professor of Microbiology
Immunotherapy; Tumor Immunology
Sarah (Sally) J. Parsons, Ph.D.
Professor of Microbiology
Molecular mechanisms of Src family tyrosine kinases in mitogenesis, tumorigenesis, and neuronal activity.
Martin A. Schwartz, Ph.D.
Professor of Microbiology
Integrin Signaling and Its Relevance to Mechanotransduction, Cancer and Vascular Disease

Microbiology Research Faculty
John D. Shannon, Ph.D. Associate Professor of Research of Microbiology Protein primary structure determination, chromatography of biomolecules, biomolecule interactions.	Angela Zarling, Ph.D. Assistant Professor of Research of Microbiology Manipulation of phosphopeptide display on cancer cells

Joint Faculty
Roger Abounader, M.D., Ph.D. Associate Professor of Neurology Roles and targeting of c-Met in brain tumors; c-Met/PTEN interactions in gliomas; PTEN/mutant-p53 interactions in gliomas; microRNAs in brain tumors	Alan F. "Rick" Horwitz, Ph.D. Professor of Cell Biology Synapse Formation and Cell Migration in Normal and Pathobiology-Adhesion, Signaling, Imaging and Proteomics Corinne M. Silva, Ph.D. Associate Professor of Medicine STAT5b signaling in tyrosine kinase-dependent and anti-estrogen resistant breast cancers

University of Virginia Health System