Microbiology Research Images

  • 3color_cortactin
  • Conjugate formation between dendritic cells, conventional and regulatory CD4+ T cells
  • Human mammary tissue stained for CK5/K8
  • MCF-7 breast cancer cells containing stress granules
  • Breast cancer cell lines (BT549) stained with dapi (blue), phalloidin (red) and pY419Src (green).
  • Breast cancer cell lines (BT549) stained with dapi (blue), phalloidin (red) and pY419Src (green)
  • Trp operon transcribed on a plasmid in Salmonella typhimurium
  • Flow cytometric analysis of B-cell development from Mybff bone marrow
  • Flow cytometric analysis of B-cell development from Mybff mb1cre bone marrow
  • H&E stain showing kidney nephritis and infiltration of lymphocytes, which contribute to the pathology of systemic lupus erythematosus.
  • H$E staining of bone marrow from healthy mice (left) and bone marrow from mice with myeloma (right) showing infiltrating malignant plasma cells
  • multispectral imaging of malignant plasma cells undergoing apoptosis, a process of self-induced cell death
  • Herpes simplex virus caption showing selected pentons (orange), hexons (red) and triplexes (green).
  • Cell infected by herpes simplex virus. Virus capsids are green. Cellular microtubules are red. Cell nucleus is blue.
  • Cell infected by herpes simplex virus. Virus capsids are green. Cellular microtubules are red. DNA extruded from the herpes simplex capsid and extended by buffer flow (left to right).
  • DNA extruded from the herpes simplex capsid and extended by buffer flow (left to right).
  • Cell infected by herpes simplex virus. Virus capsids are green. Cellular microtubules are red. DNA extruded from the herpes simplex capsid and extended by buffer NIH/3T3 cells expressing FLAG-hBAI1 (green), a transmembrane receptor for the apoptotic cell) counterstained with Alexa555-phalloidin and Hoescht. Arrows point to membrane "spikes".
  • NIH/3T3 cells expressing FLAG-hBAI1 (green), a transmembrane receptor for the apoptotic cell) counterstained with Alexa555-phalloidin and Hoescht. Arrows point to membrane "spikes".
  • Nematodes were allowed to feed on bacteria expressing dsRNA to HOPS complex members vps-11 or vps-39. Apoptotic cells (DIC, left panels) in the gonad are phagocytosed, but arrest in YFP::RAB-7(+) phagosomes (arrows, right panels). Asterisks mark poorly refractile apoptotic cells at a late stage of degradation.
  • YFP::RAB-5 (green) or CFP::RAB-7 (red) marks distinct populations of endocytic vesicles in the C. elegans adult hermaphrodite.
  • Interactions of the P4 p-Ser with the HLA-A2 heavy chain.
  • B7-B1 expresiion in hte liver of chronic HCV patients (200X) Courtesy of the Hahn Lab, Beirne Carter Center
  • Use of multispectral imaging flow cytometry to detect immune evasion strategies of Kaposi's sarcoma-associated herpesvirus (KSHV). Figure shows progressive downregulation of surface MHC-I (blue) with increasing intracellular viral load (yellow). Courtesy of the Kedes Lab
  • Microtubule bundling induced by over-expression of a tegument protein from Rhesus monkey herpesvirus. Courtesy of the Kedes Lab
  • Rhesus monkey rhadinovirus capsids (green) assembled in the nucleus of infected cells.
  • Type 1 diabetes results from immune invasion of the islets of Langerhans, with destruction of the insulin-secreting beta cells
  • Type 1 diabetes results from immune invasion of the islets of Langerhans, with destruction of the insulin-secreting beta cells
  • Localization of specific mRNAs to the tips of cell protrusions (Mili et al., Nature, 2008), Courtesy of the Macara Lab
  • Localization of specific mRNAs to the tips of cell protrusions (Mili et al., Nature, 2008), Courtesy of the Macara Lab
  • Bioluminescent Bacillus anthracis mutants struck out on a Petri dish, Courtesy of the Glomski Lab
  • Thin-section transmission electron micrograph of a human neutrophil, Courtesy of the Criss Lab
  • Scanning electron microscope image showing microvilli on the apical surface of polarized epithelial cells (MDCK cells). Courtesy of the Macara Lab
  • Courtesy of the Goldberg Lab
  • MDCK cell cyst, grown in 3D culture, Courtesy of the Macara Lab
  • Human Breast Cancer MCF7 Cells DNA-blue, Focal adhesions-white, cytoplasm-magenta
  • Drosophila Embryo with Reduced Levels of Maternal Dm I-2 Loses Synchrony of Nuclear Divisions
  • RNAi Knockdown of Phosphatase I-2 Causes Lagging Anaphase Chromosomes
  • Bacillus anthracis spore interacting with the nasal cavities of a mouse, Courtesy of the Glomski Lab
  • Composite, Macara Lab

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The faculty of the Department of Microbiology at the University of Virginia conduct research focused on immunology, cell biology, bacterial and viral pathogenesis, and the molecular basis of cancer. Our goal is not only to make inroads into understanding these complex problems, but also to train the next generation of young scientists. As you look though this internet site, we hope that you will gain a sense of the vitality in our department, the excitement of our faculty and students for their research, and the collegial environment of the University of Virginia.

Microbiology Seminar

  • 11/11 Robert L. Garcea, MD "Chaperoning Papovavirus Assembly and Disassembly."
  • 11/18 Jeremy Sanford, PhD "Deciphering the roles of protein-RNA interactions in gene expression and human disease"
  • Seminar Calendar

News

  • J. Thomas Parsons receives Jefferson Award - the highest honor that the University bestows for "Blazing New Paths in Cancer Research and Treatment"
  • Amy H. Bouton, PhD receives Robert J. Kadner Award for outstanding graduate teaching
  • Congratulations to our Chair J.Thomas Parsons, PhD who received the Distinguished Scientist Award [more]
  • 2009 Peach Peach Hungerford Award for outstanding graduate research for Karen Eisinger in the Lannigan Lab - Congratulations!
  • 2009 Wagner-Award for Anna Maria Copeland, Jay Brown Lab - Congratualtions!
  • News/Awards
  • Wagner Scholarship and Prize