Research home, Publications

Laura Bechtel

  

Laura K. Bechtel, PhD

 

 


PEER REVIEWED JOURNALS:

1.         Klimowski, L.( Bechtel, L.), Garcia, B., Schroeder, M., Shabanowitz, J., Hunt, D., and Virshup, D.  Site-specific CKI-epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling.  FEBS J. 2006 Oct;273(20):4594-602

2.         Klimowski, L. (Bechtel, L.), Garcia, B., Hunt, D. and Virshup, D.  CKIe phosphorylation of Dishevelled at Ser 139/142 attenuates Wnt signal transduction.  Dissertation (2005).

3.         Swiatek, W., Tsai, I., Klimowski, L. (Bechtel, L.), Pepler, A., Barnette, J., Yost, Virshup, D.  Regulation of casein kinase Ie activity by Wnt signaling.  J Biol Chem. (2004)  279:  13011-13017.

4.         Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski, L. (Bechtel, L.), Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray, A. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.  Genome Res. 2003 Oct;13(10):2265-70.  Epub 2003 Sep 15.

5.         Simmons, L., Reilly, D., Klimowski, L. (Bechtel, L.), T. Shantha Raju, Meng, G., Sims, P., Hong, Ky., Shields, R., Damico, L., Rancatore, P., Yansura, D.  Expression of full-length immunoglobulins in Escherichia coli:  rapid and efficient production of aglycosylated antibodies.  J. Imm. Methods (2002) 263:133-147.

6.         Klimowski, L. (Bechtel, L.), Ramaswamy, D., Tripp, C.  Molecular cloning, expression and enzymatic activity of a thioredoxin peroxidase from Dirofliaria immitis.  Mol. Biochem. Parasitology (1997) 90:297-306.

7.         Klimowski, L. (Bechtel, L.), Rayms-Keller, A., Olson, K., Yang, R., Tessari, J., Carlson, J. and Beaty, B.  Inducibility of a molecular bioreporter system by heavy metals. Environmental Toxicology and Chemistry (1996) 15:85-91.

8.         Higgs, S., Olson, K., Klimowski, L. (Bechtel, L.), Powers, A., Carlson, J., Possee, R. and Beaty, B.  Mosquito sensitivity to scorpion neurotoxin expressed in an infectious Sindbis virus vector.   Insect Mol. Bio.  (1995) 4:97-103.

BOOK CHAPTERS

  1. Holstege CP, Reilly TH, Bechtel LK.  Other agents. In McFee R & Leikin J (eds):  Emergency bioterrorism.  McGraw-Hill.  (publication pending)

  2. Lawrence, D.T., Dobmeier, S.G., Bechtel, L.K., Holstege, C.P.  Food Poisoning.  Medical Toxicology - Emergency Medicine Clinics in North America.  (2007) 25: 357-373.

  3. Bechtel, L.K., Holstege, C.P.  Criminal poisoning:  Drug-facilitated sexual assault. Medical Toxicology - Emergency Medicine Clinics in North America.(2007) 25:  499-525.

  4. Holstege, C.P.  Bechtel, L.K., Treilly, T.H., Wispelwey, B.P., Dobermeier, S.G.  Unusual but potential agents of terrorists.  Medical Toxicology - Emergency Medicine Clinics in North America. (2007) 25:  549-566.

PUBLISHED ABSTRACTS

1. Bechtel, L.K. and Holstege. Verapamil toxicity induces dysregulation of the insulin-dependent phosphatidylinositol 3-kinase pathway. Southeastern SAEM Annual Meeting. March 23-24, 2007. Wilmington, NC.

2. Bechtel, L.K. and Holstege. Verapamil toxicity induces dysregulation of the insulin-dependent phosphatidylinositol 3-kinase pathway. SAEM Annual Meeting. May 16-19, 2007. Chicago, IL. Acad Emerg Med 2007;14(5): S51.

3. Bechtel, L.K. Haverstick, D.M. and Holstege. High dose insulin reverses calcium channel blocker inhibition of glucose uptake in an adipocyte model. SAEM Annual Meeting. May 16-19, 2007. Chicago, IL. Acad Emerg Med 2007;14(5): S195.

4. Klimowski, L. (Bechtel, L.K.), Garcia, B., Hunt, D., and Virshup, D. Identification of in vivo phosphorylation sites of CKIe substrates in the Wnt signaling pathway. Wnt Signal Transduction Meeting. May 20-23, 2004. Ann Arbor, MI.

5. Klimowski, L. (Bechtel, L.K.), Schwall, R., Taylor, S. and Blumenthal, D. Protein kinase A and A-kinase anchoring proteins are differentially regulated in normal vs. oncogenic mammalian breast cancer cell lines. Summer Intern Research Symposia. August 15, 2001; S. San Francisco, CA.

6. Klimowski, L. (Bechtel, L.K.), Reilly, D. and Yansura, D. Full-length antibody expression in Escherichia coli. Genentech-Asliomar, CA 1998.

7. Tripp,C., Klimowski, L. (Bechtel, L.K.), Blehm, S. and Grieve, R. A Dirofilaria immitis cDNA clone encodes a homolog of the astacin family of zinc endopeptidases. Annual Parasitology Meeting. August 20-25, 1998.

8. Tripp, C., Klimowski, L. (Bechtel, L.K.), Ramaswamy, C. and Grieve, R. A Dirofilaria immitis larval cDNA clone encoding a homology of mammalian MIF. Keystone Symposia, Molecular Helminthology: an integrated approach. February 22-28, 1996; Santa Fe NM.

9. Tripp, C., Klimowski, L. (Bechtel, L.K.), Mika-Grieve, M., Frank, R. and Grieve, R. Identification and molecular cloning of Dirofilaria immitis genes using immune dog sera. 62nd AMCA Annual Meeting. March 24-28, 1996. Norfolk, Virginia.

PATENTS

1.         Simmons, L., Reilly, D Klimowski, L. (Bechtel, L.K.), Yansura, D.  Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes.  Issued United States Patent #6,979,556,  2005. 

2.         Klimowski, L. (Bechtel, L.K.), and Tripp C.  Parasitic helminth larval thiol specific antioxidant proteins and nucleic acid molecules. Issued United States Patent # 5,744,593, 1998; 6,031,077, 2000April 28, 1998

3.         Klimowski, L. (Bechtel, L.K.), and Tripp C Antiparasitic helminth larval thiol specific antioxidant-antibodies, and uses thereof.  Issued United States Patent # 6,489,448, 2002.