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Frederick  G.  Hayden
Degree(s): M.D.
Graduate School: Stanford University
Primary Appointment: Professor of Medicine, Infectious Diseases and International Health
Research Interests:
Antiviral agents for the prevention and treatment of respiratory viral infections

Email Address: fgh@virginia.edu
Research Description

Our research activities have focused on the application of antiviral agents for the prevention and treatment of respiratory viral infections. The scope of studies ranges from in vitro assays of viral susceptibility and antiviral mechanisms of action to clinical trials involving experimentally induced and naturally occurring infections. For example, prior work established the effectiveness of intranasal interferons in preventing transmission of rhinovirus colds, the safety and pharmacology of rimantadine HCI, the transmission of drug- resistant influenza A viruses in families, the anti-rhinovirus mechanism of action and antiviral activity of soluble ICAM-1, and the antiviral activity and clinical use of influenza neuraminidase inhibitors; oseltamivir and zanamivir, and the anti-picornavirus agent, pleconaril. Areas of current investigation include application of nucleic acid hybridization to study picornavirus epidemiology, determining the phenotypic and genotypic basis of antiviral drug resistance in rhino and influenza viruses, clinical testing of the several candidate antiviral agents for influenza and rhinovirus infections, and studies of host inflammatory response modifying agents in the pathogenesis of rhinovirus infections.

Selected Publications
  • Hayden FG, Herrington DT, Coats TL, Kim K, Cooper EC, Villano SA, Liu S, Hudson S, Pevear DC, Collett M, McKinlay M, and the Pleconaril Respiratory Infection Study Group. Efficacy and safety of oral pleconaril for treatment of colds due to picornavirus in adults: results of 2 double-blind, randomized, placebo-controlled trials. Clin Infect Dis 36: 1523-32, 2003.
  • Kaiser L, Wat C, Mills T, Mahoney P, Ward P, and Hayden F. Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations. Arch Intern Med 163: 1667-1672, 2003.
  • Fritz RS, Hayden FG, Calfee DP, Cass LMR, Peng AW, Alvord WG, Strober W, Straus SE. Nasal cytokine and chemokine responses in experimental influenza A virus infection: results of a placebo-controlled trial of intravenous zanamivir treatment. J Infect Dis 180:586-93; 1999.
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    Contact Information
      Office Address: PO Box 800473, Private Clinics, 6558, 
      Office Phone: +1 434-924-5059
      Fax Phone: +1 434-924-9065

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